Cedillo Yenni E, Moellering Douglas R, De Luca Maria
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
Nutr Health. 2025 Sep 16:2601060251378557. doi: 10.1177/02601060251378557.
Diet quality has been implicated in the development of abdominal obesity. Yet, the molecular components involved in this relationship remain largely unknown. This pilot study examined whether syndecan-4 (SDC4) may serve as a molecular link between diet quality and abdominal obesity. Serum SDC4 levels were measured in 41 women (aged 21-45) who self-identified as African American or European American. Diet quality was assessed using the healthy eating index (HEI) score derived from a food frequency questionnaire, while android percent fat was measured using dual-energy X-ray absorptiometry. Regression and mediation analyses were performed to examine the data. Significant ( < 0.05) negative correlations were observed between HEI scores and both body mass index (BMI) and android percent fat. SDC4 emerged as a significant predictor of HEI and mediated the negative associations of HEI with BMI and android percent fat, independent of race and age. Our findings suggest that SDC4 may play a key mechanistic role in linking adherence to dietary recommendations with reductions in android adiposity.
饮食质量与腹部肥胖的发展有关。然而，这种关系中涉及的分子成分在很大程度上仍不为人知。这项初步研究调查了syndecan-4（SDC4）是否可能作为饮食质量与腹部肥胖之间的分子联系。对41名自我认定为非裔美国人或欧裔美国人的女性（年龄在21 - 45岁之间）的血清SDC4水平进行了测量。饮食质量使用从食物频率问卷得出的健康饮食指数（HEI）评分进行评估，而腹部脂肪百分比则使用双能X线吸收法进行测量。进行了回归和中介分析以检验数据。观察到HEI评分与体重指数（BMI）和腹部脂肪百分比之间存在显著（<0.05）的负相关。SDC4成为HEI的显著预测因子，并介导了HEI与BMI和腹部脂肪百分比之间的负相关，且不受种族和年龄的影响。我们的研究结果表明，SDC4可能在将遵循饮食建议与减少腹部肥胖联系起来方面发挥关键的机制作用。
