Bundy D A, Thompson D E, Cooper E S, Blanchard J
Trans R Soc Trop Med Hyg. 1985;79(5):641-4. doi: 10.1016/0035-9203(85)90178-6.
The efficacy of multiple and single dose regimens of albendazole on Trichuris trichiura infection was evaluated by counting the number of worms expelled/day from two pair-matched groups of children, for nine days following therapy. The temporal patterns of worm expulsion were similar whether the children received a single 400 mg dose or two consecutive doses: no worms were passed before the second day, or after the sixth day, after intervention, and the maximum worm expulsion rate was attained on the fourth day. A second treatment six days after the first expelled no more worms. The results obtained here resemble those obtained previously with a three-day (600 mg) regimen of mebendazole in a study of heavily infected children. We conclude: that irrespective of dose, benzimidazole carbamates require the gut transit time plus 48 hours to immobilize T. trichiura; and that a single dose of albendazole is effective against light infections of T. trichiura but requires further evaluation with high intensity infections.
通过计算治疗后九天内两组配对儿童每天排出的蠕虫数量，评估了阿苯达唑多剂量和单剂量方案对鞭虫感染的疗效。无论儿童接受单次400毫克剂量还是连续两次剂量，蠕虫排出的时间模式相似：干预后第二天之前或第六天之后均无蠕虫排出，且在第四天达到最大蠕虫排出率。第一次治疗六天后进行第二次治疗，未排出更多蠕虫。此处获得的结果与之前在一项对重度感染儿童的研究中使用三天（600毫克）甲苯达唑方案获得的结果相似。我们得出结论：无论剂量如何，苯并咪唑氨基甲酸盐需要肠道转运时间加48小时来使鞭虫固定；单剂量阿苯达唑对轻度鞭虫感染有效，但对高强度感染需要进一步评估。
