Olsen Annette, Namwanje Harriet, Nejsum Peter, Roepstorff Allan, Thamsborg Stig M
DBL-Centre for Health Research and Development, Department of Disease Biology, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 57, DK-1871 Frederiksberg C, Denmark.
Trans R Soc Trop Med Hyg. 2009 May;103(5):443-6. doi: 10.1016/j.trstmh.2008.12.010. Epub 2009 Feb 7.
Three groups of Trichuris trichiura-infected school-age children were treated with one dose 400mg albendazole, 100mg mebendazole twice daily for 3 d, or 100mg mebendazole twice daily for 5 d. The albendazole study investigated cure and egg reduction rates and found that only 5 of 66 infected children were egg-negative 7 d post-treatment, giving a cure rate of 8% and a geometric mean egg reduction rate of 89%. However, at day 14 post-treatment, all children were again egg-positive with significantly higher egg counts than at day 7 (P<0.001). The two mebendazole studies aimed for the recovery of adult T. trichiura worms. After the 3 d course of mebendazole treatment, only four worms were recovered on days 3-5 after start of treatment from 2 of 34 infected children. With the 5 d course of mebendazole treatment, 10 of 21 infected children expelled a total of 27 worms. In the last case the first worm appeared on day 4 post-treatment, and the highest number of worms was recovered when the study ended at day 7. In conclusion, even with the longest treatment regimen and collecting stool samples over seven consecutive days, only very few worms were recovered. The results of this study suggest that alternative drugs and/or alternative regimens in current control programmes against T. trichiura need renewed attention.
三组感染毛首鞭形线虫的学龄儿童分别接受了一剂400毫克阿苯达唑治疗、每日两次每次100毫克甲苯达唑共治疗3天，或每日两次每次100毫克甲苯达唑共治疗5天。阿苯达唑研究调查了治愈率和虫卵减少率，发现66名受感染儿童中只有5名在治疗后7天虫卵呈阴性，治愈率为8%，几何平均虫卵减少率为89%。然而，在治疗后第14天，所有儿童的虫卵再次呈阳性，且虫卵计数显著高于第7天（P<0.001）。两项甲苯达唑研究旨在回收成虫毛首鞭形线虫。在甲苯达唑治疗3天疗程后，34名受感染儿童中有2名在治疗开始后第3至5天仅回收了4条虫。在甲苯达唑治疗5天疗程中，21名受感染儿童中有10名排出了总共27条虫。在最后一个病例中，第一条虫在治疗后第4天出现，当研究在第7天结束时回收的虫数量最多。总之，即使采用最长的治疗方案并连续7天采集粪便样本，也仅回收了很少的虫。本研究结果表明，当前针对毛首鞭形线虫的控制项目中的替代药物和/或替代方案需要重新关注。
