Pudifin D J, Duursma J, Brain P
Clin Exp Immunol. 1977 Aug;29(2):256-60.
Autoimmune thyroiditis was induced in two vervet monkeys by immunizing them with human thyroid extract. As expected, both animals developed cytotoxic antibodies which were active against human thyroid and other human cells in tissue culture. In addition, a second serum factor was detected. This was capable of sensitizing human thyroid (and other) cells and rendering them susceptible to killing by normal lymphocytes. This finding implicates antibody-dependent cell-mediated cytotoxicity in the pathogenesis of autoimmune thyroiditis.
通过用人甲状腺提取物免疫两只绿猴诱发自身免疫性甲状腺炎。不出所料，两只动物都产生了细胞毒性抗体，这些抗体在组织培养中对人甲状腺及其他人类细胞具有活性。此外，还检测到了第二种血清因子。这种因子能够使人类甲状腺（及其他）细胞致敏，并使其易于被正常淋巴细胞杀伤。这一发现表明抗体依赖性细胞介导的细胞毒性在自身免疫性甲状腺炎的发病机制中起作用。
