Li Shuxin, Cao Hongliang, Zhang Yueqiu, Yang Tong, Shi Ruihong, Wei Wei
Department of Urology, The First Hospital of Jilin University, Changchun, China.
Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
Medicine (Baltimore). 2025 Sep 12;104(37):e44414. doi: 10.1097/MD.0000000000044414.
Testosterone deficiency is increasingly recognized as a significant public health challenge, strongly correlated with obesity. The link between the body roundness index (BRI) and the prevalence of testosterone deficiency is unclear. This research aims to examine these relationships. To investigate the relationship between BRI and the risk of testosterone deficiency, data from the National Health and Nutrition Examination Survey (NHANES) 2013 to 2016 were examined. This study employed multiple logistic regression and smoothed curve fitting to investigate the relationship between BRI and testosterone deficiency. The stability of the associations was also explored through subgroup analyses, interaction tests, and assessment of threshold effects. The study included 3663 participants, with 25.82% exhibiting testosterone deficiency. Upon adjustment for confounding variables, a positive association was detected between BRI and the prevalence of testosterone deficiency (OR = 1.29, 95% CI: 1.23-1.35, P < .0001). The smooth curve fitting indicated a nonlinear positive correlation between BRI and the prevalence of testosterone deficiency. The turning point of the smooth curve fit between BRI and testosterone deficiency was 4.04. When the BRI value was above 4.04, the association between BRI and testosterone deficiency was OR = 1.32, 95% CI: 1.25, 1.39, P < .0001. The independent positive associations between BRI and the prevalence of testosterone deficiency remained consistent across all subgroups (P for interaction >.05). Higher BRI was associated with a higher risk of testosterone deficiency in American adult men.
睾酮缺乏日益被视为一项重大的公共卫生挑战，与肥胖密切相关。身体圆润度指数（BRI）与睾酮缺乏患病率之间的联系尚不清楚。本研究旨在探讨这些关系。为了研究BRI与睾酮缺乏风险之间的关系，对2013年至2016年美国国家健康与营养检查调查（NHANES）的数据进行了分析。本研究采用多元逻辑回归和平滑曲线拟合来研究BRI与睾酮缺乏之间的关系。还通过亚组分析、交互作用检验和阈值效应评估来探讨关联的稳定性。该研究纳入了3663名参与者，其中25.82%表现出睾酮缺乏。在对混杂变量进行调整后，发现BRI与睾酮缺乏患病率之间存在正相关（OR = 1.29，95%CI：1.23 - 1.35，P <.0001）。平滑曲线拟合表明BRI与睾酮缺乏患病率之间存在非线性正相关。BRI与睾酮缺乏之间平滑曲线拟合的转折点为4.04。当BRI值高于4.04时，BRI与睾酮缺乏之间的关联为OR = 1.32，95%CI：1.25，1.39，P <.0001。在所有亚组中，BRI与睾酮缺乏患病率之间的独立正相关均保持一致（交互作用P>.05）。在美国成年男性中，较高的BRI与较高的睾酮缺乏风险相关。
