Priego-Corredor Anabel, Del Saiz-Álvarez María Rocío, Vila-Soriano Anna, Castro-López Jorge, Herrería-Bustillo Vicente
Veterinary Teaching Hospital of the Catholic University of Valencia (VTHCUV), Valencia, Spain.
AniCura Valencia Sur Veterinary Hospital, Internal Medicine, Silla, Spain.
J Vet Intern Med. 2025 Sep-Oct;39(5):e70201. doi: 10.1111/jvim.70201.
Hyperfibrinolysis (HFL) has not been well described in cats.
HYPOTHESIS/OBJECTIVES: Identify risk factors associated with HFL in cats and evaluate its association with survival. Our hypotheses were that cats share similar conditions as dogs and humans with HFL and that it is associated with a worse prognosis.
A total of 154 client-owned cats had thromboelastography (TEG) performed because of a variety of clinical conditions.
Retrospective case-control study. Cases were defined as cats with HFL (clot lysis at 30 min [LY30] ≥ 5% or clot lysis at 60 min [LY60] ≥ 10% or both) and controls were cats that had TEG performed but without HFL. Signalment, conditions that may alter fibrinolysis, TEG variables, indications to perform TEG, and outcome were recorded.
Fifty-two cats (33.8%) with HFL and 102 controls (66.2%) were included. Demographic variables were similar between groups. Both liver disease (odds ratio [OR], 5.0; 95% confidence interval [CI], 2.4-10.6; p < 0.001) and the presence of cavitary effusion (OR, 5.9; 95% CI, 2.8-12.4; p < 0.001) were important risk factors for HFL. Cats with heart disease were less likely to have HFL (OR, 0.2; 95% CI, 0.1-0.5; p < 0.001). The presence of HFL was not associated with worse outcome (p = 0.84). Cats with HFL more often were hypocoagulable, whereas cats without HFL more often were hypercoagulable (p < 0.001).
Liver disease and cavitary effusion are risk factors for HFL in cats. The presence of HFL did not affect survival.
猫的高纤溶状态（HFL）尚未得到充分描述。
假设/目标：确定猫发生HFL的相关危险因素，并评估其与生存的关系。我们的假设是，猫与患有HFL的狗和人类有相似的情况，且它与较差的预后相关。
总共154只客户拥有的猫因各种临床情况接受了血栓弹力图（TEG）检查。
回顾性病例对照研究。病例定义为患有HFL的猫（30分钟时的凝块溶解[LY30]≥5%或60分钟时的凝块溶解[LY60]≥10%或两者皆有），对照为接受了TEG检查但无HFL的猫。记录品种、可能改变纤溶的情况、TEG变量、进行TEG检查的指征以及结果。
纳入了52只（33.8%）患有HFL的猫和102只对照（66.2%）。两组间人口统计学变量相似。肝病（优势比[OR]，5.0；95%置信区间[CI]，2.4 - 10.6；p < 0.001）和空洞性积液的存在（OR，5.9；95% CI，2.8 - 12.4；p < 0.001）都是HFL的重要危险因素。患有心脏病的猫发生HFL的可能性较小（OR，0.2；95% CI，0.1 - 0.5；p < 0.001）。HFL的存在与较差的结果无关（p = 0.84）。患有HFL的猫更常出现低凝状态，而无HFL的猫更常出现高凝状态（p < 0.001）。
肝病和空洞性积液是猫发生HFL的危险因素。HFL的存在不影响生存。
