Min Shasha, Guo Mengmeng, Du Jianuo, Chen Jiaohuang, Shen Yanting, Yuan Fuwen, Wang Zhong, Cai Zhonglin
School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai, China.
Department of Urology and Andrology, Shanghai Pudong New Area Gongli Hospital, Shanghai, China.
Front Oncol. 2025 Sep 1;15:1609712. doi: 10.3389/fonc.2025.1609712. eCollection 2025.
Prostate cancer (PCa) is one of the most common malignant tumors in men, with increasing incidence and mortality rates, and its treatment still faces many challenges and unmet needs. ELAVL1 (human antigen R, HuR) is an RNA-binding protein that plays a crucial role in the development and progression of various cancers. Studies have shown that ELAVL1 is highly expressed in PCa and that inhibiting its expression significantly reduces prostate cell proliferation and metastasis. However, the clinical application of ELAVL1-targeting therapies remains limited by the lack of effective delivery strategies. In this context, recent advances in nanodelivery systems offer promising solutions, providing both enhanced targeting efficiency and insights for future prostate cancer treatment strategies.
This review aims to explore the potential of ELAVL1-targeted therapy based on nanodelivery systems in PCa, analyze its advantages and challenges, and provide insights into future research directions.
A systematic review of recent literature summarizing the expression characteristics and biological functions of ELAVL1 in PCa was conducted. Additionally, the advantages, challenges, and applications of various nanomaterials in cancer therapy are discussed.
Nanodelivery systems have shown significant potential in the treatment of prostate cancer.
前列腺癌（PCa）是男性最常见的恶性肿瘤之一，其发病率和死亡率不断上升，其治疗仍面临许多挑战和未满足的需求。ELAVL1（人类抗原R，HuR）是一种RNA结合蛋白，在各种癌症的发生和发展中起关键作用。研究表明，ELAVL1在前列腺癌中高表达，抑制其表达可显著降低前列腺细胞的增殖和转移。然而，靶向ELAVL1疗法的临床应用仍受限于缺乏有效的递送策略。在此背景下，纳米递送系统的最新进展提供了有前景的解决方案，为未来前列腺癌治疗策略提供了更高的靶向效率和见解。
本综述旨在探讨基于纳米递送系统的ELAVL1靶向治疗在前列腺癌中的潜力，分析其优势和挑战，并为未来研究方向提供见解。
对近期文献进行系统综述，总结ELAVL1在前列腺癌中的表达特征和生物学功能。此外，还讨论了各种纳米材料在癌症治疗中的优势、挑战和应用。
纳米递送系统在前列腺癌治疗中显示出巨大潜力。
