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番木瓜对牙周病的影响：一项系统评价与Meta分析

The Effect of Carica Papaya on Periodontal Disease: A Systematic Review and Meta-Analysis.

作者信息

Saberi Zahra, Rahimi Alireza, Feizi Awat, Golestannejad Zahra, Saidi Zahra, Jafari Zahra

机构信息

Department of Oral and Maxillofacial Medicine, Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.

Health Information Technology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Adv Biomed Res. 2025 Aug 26;14:95. doi: 10.4103/abr.abr_223_24. eCollection 2025.

DOI:10.4103/abr.abr_223_24
PMID:40958927
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12435709/
Abstract

BACKGROUND

The aim of the present systematic review and meta-analysis was to investigate the effect of Carica papaya on periodontal disease in the adult population.

MATERIALS AND METHODS

A systematic search was performed using the PubMed, Web of Science, Embase, and Cochrane library databases up to June 2021 using related keywords for randomized clinical trials that evaluated the effect of Carica papaya on gingival index (GI), plaque index (PI), and papilla bleeding index (PBI) in the intervention group compared to control group.

RESULTS

A total of five eligible studies involving 206 participants were included in the systematic review and meta-analysis. GI score significantly decreased in the intervention group at the end of the treatment compared to the baseline (ES = -0.64; 95% CI = -0.85--0.42; I = 90.4%; < 0.001). Furthermore, patients in the intervention group had significantly lower GI (weighted mean difference = -0.28; 95% CI = -0.45--0.10; I = 98.2%; < 0.001) and PI (weighted mean difference = -0.36; 95% CI = -0.59--0.14; I = 99.3; < 0.001) scores compared with control individuals. However, no significant difference observed between the two groups regarding PBI score.

CONCLUSION

Despite study limitations, this systematic review and meta-analysis highlighted the effective role of oral care products containing Carica papaya for the treatment of periodontal diseases by improving indices like GI and PI.

摘要

背景

本系统评价和荟萃分析的目的是研究番木瓜对成年人群牙周疾病的影响。

材料与方法

截至2021年6月，使用PubMed、科学网、Embase和Cochrane图书馆数据库进行系统检索，使用相关关键词查找评估番木瓜对干预组与对照组牙龈指数（GI）、菌斑指数（PI）和龈乳头出血指数（PBI）影响的随机临床试验。

结果

系统评价和荟萃分析共纳入5项符合条件的研究，涉及206名参与者。与基线相比，干预组在治疗结束时GI评分显著降低（效应量=-0.64；95%置信区间=-0.85--0.42；I²=90.4%；P<0.001）。此外，与对照组相比，干预组患者的GI（加权平均差=-0.28；95%置信区间=-0.45--0.10；I²=98.2%；P<0.001）和PI（加权平均差=-0.36；95%置信区间=-0.59--0.14；I²=99.3%；P<0.001）评分显著更低。然而，两组在PBI评分方面未观察到显著差异。

结论

尽管存在研究局限性，但本系统评价和荟萃分析强调了含番木瓜的口腔护理产品通过改善GI和PI等指标对牙周疾病治疗的有效作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d783/12435709/c6a04eb9ac85/ABR-14-95-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d783/12435709/6820f6938a9d/ABR-14-95-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d783/12435709/1c7f3c9b9165/ABR-14-95-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d783/12435709/816b74581390/ABR-14-95-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d783/12435709/be93def27639/ABR-14-95-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d783/12435709/bd0fa9951fec/ABR-14-95-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d783/12435709/c6a04eb9ac85/ABR-14-95-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d783/12435709/6820f6938a9d/ABR-14-95-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d783/12435709/1c7f3c9b9165/ABR-14-95-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d783/12435709/816b74581390/ABR-14-95-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d783/12435709/be93def27639/ABR-14-95-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d783/12435709/bd0fa9951fec/ABR-14-95-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d783/12435709/c6a04eb9ac85/ABR-14-95-g006.jpg

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本文引用的文献

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Periodontal disease and quality of life: Umbrella review of systematic reviews.牙周病与生活质量：系统评价的伞式综述。
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ScientificWorldJournal. 2020 May 28;2020:2146160. doi: 10.1155/2020/2146160. eCollection 2020.
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Periodontal Disease: A Risk Factor for Diabetes and Cardiovascular Disease.牙周病：糖尿病和心血管疾病的危险因素。
Int J Mol Sci. 2019 Mar 20;20(6):1414. doi: 10.3390/ijms20061414.
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Effect of a Toothpaste/Mouthwash Containing Leaf Extract on Interdental Gingival Bleeding: A Randomized Controlled Trial.含 叶提取物的牙膏/漱口水对牙间牙龈出血的影响：一项随机对照试验。
Int J Environ Res Public Health. 2018 Nov 27;15(12):2660. doi: 10.3390/ijerph15122660.
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