Department of Zoology, Banaras Hindu University, Varanasi, UP, India.
Cancer and Radiation Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Daru. 2020 Dec;28(2):735-744. doi: 10.1007/s40199-020-00348-7. Epub 2020 May 5.
Papaya (Carica papaya Linn.) belongs to the family Caricaceae and is well known for its therapeutic and nutritional properties all over the world. The different parts of the papaya plant have been used since ancient times for its therapeutic applications. Herein, we aimed to review the anticancer, anti-inflammatory, antidiabetic and antiviral activities of papaya leaf.
All information presented in this review article regarding the therapeutic application of Carica papaya leaf extract has been acquired by approaching various electronic databases, including Scopus, Google scholar, Web of science, and PubMed. The keywords Carica papaya, anticancer, anti-inflammatory, immunomodulatory, and phytochemicals were explored until December 2019.
The papaya plant, including fruit, leaf, seed, bark, latex, and their ingredients play a major role in the management of disease progression. Carica papaya leaf contains active components such as alkaloids, glycosides, tannins, saponins, and flavonoids, which are responsible for its medicinal activity. Additionally, the leaf juice of papaya increases the platelet counts in people suffering from dengue fever.
The major findings revealed that papaya leaf extract has strong medicinal properties such as antibacterial, antiviral, antitumor, hypoglycaemic and anti-inflammatory activity. Furthermore, clinical trials are needed to explore the medicative potential of papaya leaf. Graphical abstract Graphical abstract showing the medicinal properties of Carica papaya leaf.
木瓜（Carica papaya Linn.）属于番木瓜科，因其具有治疗和营养特性而在世界各地闻名。木瓜植物的不同部位自古以来就因其治疗用途而被使用。在此，我们旨在综述木瓜叶的抗癌、抗炎、抗糖尿病和抗病毒活性。
本综述文章中关于木瓜叶提取物治疗应用的所有信息都是通过查阅各种电子数据库（包括 Scopus、Google Scholar、Web of Science 和 PubMed）获得的。检索的关键词为 Carica papaya、anticancer、anti-inflammatory、immunomodulatory 和 phytochemicals，检索时间截至 2019 年 12 月。
木瓜植物，包括果实、叶子、种子、树皮、乳胶及其成分，在疾病进展的管理中起着重要作用。木瓜叶含有生物碱、糖苷、单宁、皂苷和类黄酮等活性成分，这些成分是其药用活性的原因。此外，木瓜叶汁可增加登革热患者的血小板计数。
主要发现表明，木瓜叶提取物具有很强的药用特性，如抗菌、抗病毒、抗肿瘤、降血糖和抗炎活性。此外，还需要进行临床试验来探索木瓜叶的药用潜力。
