Ongarj Jomkwan, Intapiboon Porntip, Tanner Rachel, Pinpathomrat Nawamin
Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
Department of Biology, University of Oxford, Oxford, United Kingdom.
Front Immunol. 2025 Sep 1;16:1625748. doi: 10.3389/fimmu.2025.1625748. eCollection 2025.
Tuberculosis (TB) is an infectious disease caused by (), with approximately 10 million new cases reported worldwide annually. Patients with immunocompromised states or those receiving immunosuppressive therapy for autoimmune diseases are at higher risk of infection or reactivation. The chronic autoimmune disease, systemic lupus erythematosus (SLE), is associated with a higher risk of infection and TB disease during conventional treatment with corticosteroids and immunosuppressants. However, whether risk of TB is influenced by the immune disturbances associated with active SLE when patients are not receiving immunosuppressant treatment remains unclear. In this review, we describe the pathogenesis of TB and SLE and consider how autoimmune responses in SLE could influence TB risk.
结核病（TB）是一种由（）引起的传染病，全球每年报告约1000万新病例。免疫功能低下的患者或因自身免疫性疾病接受免疫抑制治疗的患者感染或复发的风险更高。慢性自身免疫性疾病系统性红斑狼疮（SLE）在使用皮质类固醇和免疫抑制剂进行常规治疗期间，感染和结核病的风险更高。然而，当患者未接受免疫抑制治疗时，活动性SLE相关的免疫紊乱是否会影响结核病风险仍不清楚。在本综述中，我们描述了结核病和SLE的发病机制，并探讨SLE中的自身免疫反应如何影响结核病风险。
