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早发性多关节痛风:一例报告

Early-Onset Polyarticular Gout: A Case Report.

作者信息

Kose Lara

机构信息

Department of Medicine, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.

出版信息

Cureus. 2025 Aug 15;17(8):e90199. doi: 10.7759/cureus.90199. eCollection 2025 Aug.

DOI:10.7759/cureus.90199
PMID:40959331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12434384/
Abstract

Gout is a form of arthritis involving the inflammatory response to the deposition of monosodium urate crystals. This is a case of a 39-year-old male who presents with significant polyarticular gout with a serum urate level of 10.2 mg/dL. He was considered to have early-onset polyarticular gout. Risk factors include comorbid hypertension and chronic kidney disease. Challenges arise when considering treatment options given these comorbidities while aiming to manage the patient's symptoms effectively.

摘要

痛风是一种关节炎,涉及对尿酸单钠晶体沉积的炎症反应。这是一例39岁男性患者,表现为严重的多关节痛风,血清尿酸水平为10.2mg/dL。他被认为患有早发性多关节痛风。危险因素包括合并高血压和慢性肾脏病。在考虑治疗方案时,鉴于这些合并症,同时又要有效控制患者症状,就会出现挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea55/12434384/38e967b7dd64/cureus-0017-00000090199-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea55/12434384/52ad1202d081/cureus-0017-00000090199-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea55/12434384/34a077a7b5c2/cureus-0017-00000090199-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea55/12434384/38e967b7dd64/cureus-0017-00000090199-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea55/12434384/52ad1202d081/cureus-0017-00000090199-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea55/12434384/34a077a7b5c2/cureus-0017-00000090199-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea55/12434384/38e967b7dd64/cureus-0017-00000090199-i03.jpg

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本文引用的文献

1
Gout.痛风
Ann Intern Med. 2025 Mar;178(3):ITC33-ITC48. doi: 10.7326/ANNALS-24-03951. Epub 2025 Mar 11.
2
The comprehensive role of dual-energy CT in gout as an advanced diagnostic innovation.双能CT在痛风诊断中作为一种先进诊断创新技术的综合作用。
Skeletal Radiol. 2024 Dec 17. doi: 10.1007/s00256-024-04856-4.
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Gout and its management.痛风及其治疗。
Intern Med J. 2024 May;54(5):716-723. doi: 10.1111/imj.16382. Epub 2024 Apr 23.
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Early-onset gout.早发性痛风。
Joint Bone Spine. 2024 Sep;91(5):105704. doi: 10.1016/j.jbspin.2024.105704. Epub 2024 Feb 7.
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Safety and efficacy of colchicine in crystal-induced arthritis flare in 54 patients with severe chronic kidney disease.柳氮磺胺吡啶治疗慢性肾脏病并发晶体性关节炎急性发作的安全性和有效性。
RMD Open. 2024 Jan 31;10(1):e003872. doi: 10.1136/rmdopen-2023-003872.
6
The inflammation process of gout arthritis and its treatment.痛风性关节炎的炎症过程及其治疗。
J Adv Pharm Technol Res. 2023 Jul-Sep;14(3):166-170. doi: 10.4103/japtr.japtr_144_23. Epub 2023 Jul 28.
7
Environmental Triggers of Hyperuricemia and Gout.环境因素与高尿酸血症及痛风
Rheum Dis Clin North Am. 2022 Nov;48(4):891-906. doi: 10.1016/j.rdc.2022.06.009.
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2020 American College of Rheumatology Guideline for the Management of Gout.2020年美国风湿病学会痛风管理指南
Arthritis Care Res (Hoboken). 2020 Jun;72(6):744-760. doi: 10.1002/acr.24180. Epub 2020 May 11.
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Gout and hyperuricaemia in the USA: prevalence and trends.美国的痛风和高尿酸血症:患病率和趋势。
Rheumatology (Oxford). 2019 Dec 1;58(12):2177-2180. doi: 10.1093/rheumatology/kez196.
10
Purine-rich foods intake and recurrent gout attacks.高嘌呤食物摄入与痛风复发。
Ann Rheum Dis. 2012 Sep;71(9):1448-53. doi: 10.1136/annrheumdis-2011-201215. Epub 2012 May 30.