Veterans Affairs Nebraska-Western Iowa Health Care System, 4101 Woolworth Avenue, Omaha, NE 68105, USA; Department of Internal Medicine, University of Nebraska Medical Center, 986270 Nebraska Medical Center, Omaha, NE 68198-6270, USA.
Veterans Affairs Nebraska-Western Iowa Health Care System, 4101 Woolworth Avenue, Omaha, NE 68105, USA; Department of Internal Medicine, University of Nebraska Medical Center, 986270 Nebraska Medical Center, Omaha, NE 68198-6270, USA.
Rheum Dis Clin North Am. 2022 Nov;48(4):891-906. doi: 10.1016/j.rdc.2022.06.009.
Gout is the most prevalent type of inflammatory arthritis worldwide and environmental factors contribute to hyperuricemia and risk for gout flare. Causes of hyperuricemia include increased purine consumption from meat, alcohol, and high fructose corn syrup as well as medications such as cyclosporine, low-dose aspirin, or diuretics. Triggers for gout flares include increased purine consumption and medication use such as urate lowering therapy and diuretics. Environmental exposures including lead exposure, particulate matter exposure, temperature fluctuations, and physiologic stress have been found to trigger flares. In the right clinical scenario, these factors should be considered when treating gout patients.
痛风是全球最常见的炎症性关节炎，环境因素导致高尿酸血症和痛风发作风险增加。高尿酸血症的原因包括肉类、酒精和高果糖玉米糖浆中嘌呤的摄入量增加，以及环孢素、小剂量阿司匹林或利尿剂等药物。痛风发作的诱因包括嘌呤摄入量增加和药物使用，如尿酸降低治疗和利尿剂。已发现环境暴露，包括铅暴露、颗粒物暴露、温度波动和生理应激，可引发发作。在适当的临床情况下，在治疗痛风患者时应考虑这些因素。
