Stafylidis Christos, Patsialos Iraklis, Stefanou Dimitra, Lakiotaki Eleftheria, Diamantopoulos Panagiotis
Hematology Unit, First Department of Internal Medicine, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, GRC.
First Department of Pathology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, GRC.
Cureus. 2025 Aug 16;17(8):e90223. doi: 10.7759/cureus.90223. eCollection 2025 Aug.
Patients with chronic lymphocytic leukemia (CLL) have an increased risk for developing secondary malignancies (SMs), which usually follow an aggressive clinical course and are associated with unfavorable survival rates. Herein, we describe a patient diagnosed with CLL, who also presented with uncommon findings such as extremely elevated alkaline phosphatase levels, abnormal coagulation studies, and leucoerythroblastic reaction, that ultimately resulted in the diagnosis of concurrent metastatic prostate cancer. Early recognition of findings indicative of SM in CLL patients, even during early stages, is crucial, and physicians should stay alert. Furthermore, CLL patients should undergo more frequent screening tests for cancer as compared to the general population.
慢性淋巴细胞白血病（CLL）患者发生继发性恶性肿瘤（SMs）的风险增加，这些继发性恶性肿瘤通常呈侵袭性临床病程，且生存率不佳。在此，我们描述了一名被诊断为CLL的患者，该患者还出现了一些不常见的表现，如碱性磷酸酶水平极度升高、凝血检查异常和白细胞幼红细胞反应，最终诊断为并发转移性前列腺癌。即使在早期阶段，早期识别CLL患者中提示SM的表现也至关重要，医生应保持警惕。此外，与普通人群相比，CLL患者应更频繁地接受癌症筛查测试。
