Li Zhuo-Han, Wang Xin-Yao, Luo Qi
Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, China.
School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
Front Cardiovasc Med. 2025 Sep 1;12:1637252. doi: 10.3389/fcvm.2025.1637252. eCollection 2025.
Advanced glycation end products (AGEs) are deleterious to tissues , arising from the process of non-enzymatic glycation (NEG), also referred to as the Maillard Reaction, which facilitates the non-enzymatic modification of biomolecules by saccharides. AGEs are integral to the physiological and pathophysiological processes associated with senescence, cardiovascular diseases (CVDs), neurodegenerative and neuroinflammatory diseases, diabetes mellitus (DM) and its complications, autoimmune and rheumatic inflammatory diseases, bone-degenerative diseases, and chronic renal diseases. Both endogenous AGEs and exogenous dietary AGEs can affect the structures and functions of proteins and lipids in cardiovascular tissues and the extracellular matrix of cardiovascular cells by inducing oxidative stress and inflammatory responses, causing direct cell and tissue dysfunction, and activating subsequent signaling pathways mediated by the AGE-RAGE axis. This review focuses on the roles and mechanisms of AGEs in CVDs, from cardiovascular tissues to concrete diseases like heart failure, valvular heart disease, and so on, together with the corresponding treatment and prevention strategies, aiming to provide a comprehensive overview of the roles of AGEs in CVDs and corresponding therapeutic measures.
晚期糖基化终末产物（AGEs）对组织有害，其产生于非酶糖基化（NEG）过程，该过程也被称为美拉德反应，它促使糖类对生物分子进行非酶修饰。AGEs在与衰老、心血管疾病（CVD）、神经退行性和神经炎症性疾病、糖尿病（DM）及其并发症、自身免疫性和风湿性炎症性疾病、骨退行性疾病以及慢性肾脏疾病相关的生理和病理生理过程中起着不可或缺的作用。内源性AGEs和外源性膳食AGEs均可通过诱导氧化应激和炎症反应，影响心血管组织中蛋白质和脂质的结构与功能以及心血管细胞的细胞外基质，导致细胞和组织直接功能障碍，并激活由AGE-RAGE轴介导的后续信号通路。本综述重点关注AGEs在心血管疾病中的作用和机制，从心血管组织到诸如心力衰竭、心脏瓣膜病等具体疾病，同时探讨相应的治疗和预防策略，旨在全面概述AGEs在心血管疾病中的作用及相应治疗措施。
