Mi Yuwei, Wang Yu, Hu Jieqiong, Hua Shanshan, Wang Lanlan, Yang Jianhong, Zhang Xiaoqin, Ji Yunxin
Department of Psychosomatic Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Department of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Front Neurol. 2025 Sep 1;16:1618240. doi: 10.3389/fneur.2025.1618240. eCollection 2025.
Sleep disturbance is common in patients with cerebral small vessel disease (CSVD). The impact of insomnia on cortical activation in CSVD patients and its association with sleep quality remains unclear. Our study used functional near-infrared pectroscopy (fNIRS) to investigate differences in cortex activation in CSVD patients with sleep disturbance (CSVD + S) and CSVD patients without sleep disturbance (CSVD - S) during the verbal fluency task (VFT), and further explored its relationship with sleep quality.
59 CSVD + S and 69 CSVD - S matched for age, gender, and educational level were recruited. Sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). fNIRS was used to assess frontotemporal activation in CSVD patients during the VFT.
The prevalence of sleep disturbance in CSVD patients was 46.01%. Compared to CSVD - S, CSVD + S exhibited lower cortex activation in the bilateral medial prefrontal cortex (mPFC) and dorsolateral prefrontal cortex (DLPFC) (false discovery rate corrected < 0.05). Correlation analysis showed bilateral mPFC and DLPFC activation negatively correlateed with PSQI scores in CSVD patients. Further stepwise multiple linear regression found right mPFC activation had the strongest negative correlation with PSQI scores after adjusting for confounding factors.
Our study used fNIRS to demonstrate that CSVD patients with sleep disturbance showed poorer prefrontal cortex activation during the VFT, which is associated with poorer sleep quality.
睡眠障碍在脑小血管疾病（CSVD）患者中很常见。失眠对CSVD患者皮质激活的影响及其与睡眠质量的关系尚不清楚。我们的研究使用功能近红外光谱（fNIRS）来调查睡眠障碍的CSVD患者（CSVD + S）和无睡眠障碍的CSVD患者（CSVD - S）在言语流畅性任务（VFT）期间皮质激活的差异，并进一步探讨其与睡眠质量的关系。
招募了59名年龄、性别和教育水平相匹配的CSVD + S患者和69名CSVD - S患者。通过匹兹堡睡眠质量指数（PSQI）评估睡眠质量。使用fNIRS评估CSVD患者在VFT期间的额颞叶激活情况。
CSVD患者中睡眠障碍的患病率为46.01%。与CSVD - S相比，CSVD + S在双侧内侧前额叶皮质（mPFC）和背外侧前额叶皮质（DLPFC）的皮质激活较低（错误发现率校正<0.05）。相关性分析表明，CSVD患者双侧mPFC和DLPFC激活与PSQI评分呈负相关。进一步的逐步多元线性回归发现，在调整混杂因素后，右侧mPFC激活与PSQI评分的负相关性最强。
我们的研究使用fNIRS证明，睡眠障碍的CSVD患者在VFT期间前额叶皮质激活较差，这与较差的睡眠质量有关。
