Hubbard Gary P, Griffen Corbin, Capener Rebecca, Wyer Nicky, Martin Rebecca, Raif Rachel, Green Lisa, Sutcliffe Sheryl, Michaels Elizabeth, Dube Yvonne, Bates Johanna, Bidgood Alina, Brici Claudiu, Griffith Daniel J, Meanwell Hannah, Diamond Elizabeth, Lennon Charlotte, Lewis Louise, Chandler Lyndsay, Szymanski Lisa, Ward Jane, Banks Cerian, Nosworthy Katharine, Glanville Natasha, Richardson Sarah, Hardy Maura, Morris Samantha, Robinson Carys, Lumsdon Anna, Hatchett Naomi, Allan Lindsey, McNaughton Robyn, Campbell Alison, Baxter Janet, Owen Stephanie, Blackburn Nola, Tripp Emma, Hitchings Helen, Cooper Sheldon C, McCloskey Ann, Lewis Heidi, Stratton Rebecca J
Clinical Research, Nutricia Ltd., Trowbridge, United Kingdom.
Independent Researcher, Norfolk, United Kingdom.
Front Nutr. 2025 Sep 1;12:1621993. doi: 10.3389/fnut.2025.1621993. eCollection 2025.
There is an emerging need for plant-based options for home enteral tube feeding (HETF) patients, however their long-term efficacy and safety needs to be established.
Forty-one HETF patients (age: 51 years (SD 23); range 19-84 years; 54% male) participated in a multi-center, prospective, single-arm, open label, 13-month intervention study of a plant-based, high energy, high protein (2 kcaL/mL and 10 g protein/100 mL) enteral tube feed with or without added fiber (1.5 g/100 mL). Seventeen patients continued on the plant-based feed beyond day 28 (28 D) with a 6- and 13-month follow-up (6 M and 13 M). Outcomes included gastrointestinal tolerance (GI), anthropometrics, muscle strength and function (handgrip strength, 30-s chair stand test (30SCST)), dietary intake, total daily feed volume and time for feeding, and safety.
Compared to patient's baseline feeding regimen, patients using the plant-based feed reported: greater absence of GI symptoms at all time points (+7-12%, ≤ 0.04); a reduced incidence and intensity of GI symptoms: bloating, burping at 28 D ( < 0.05) and constipation, flatulence at 13 M ( < 0.05); improved physical function between 6 M and 13 M (+2 30SCST repetitions, = 0.02), with maintenance of body weight, calf circumference and handgrip strength; total protein intake increased at all time points (+0.2-0.3 g/kg/day, < 0.05); and total daily feed volume (-225 to -264 mL/day, < 0.05) and estimated time for pump feeding (-2 h/day, < 0.05) reduced at all time points.
This longitudinal study highlights that a plant-based (vegan-suitable) high energy, high protein enteral tube feed has good tolerance in HETF patients, positive long-term effects on protein intake and potential benefits on physical function.
对于家庭肠内管饲（HETF）患者而言，对植物性选择的需求日益凸显，然而其长期疗效和安全性仍有待确定。
41名HETF患者（年龄：51岁（标准差23）；范围19 - 84岁；54%为男性）参与了一项多中心、前瞻性、单臂、开放标签的为期13个月的干预研究，该研究针对一种植物性、高能量、高蛋白（2千卡/毫升和10克蛋白质/100毫升）的肠内管饲产品，添加或不添加纤维（1.5克/100毫升）。17名患者在第28天（28D）后继续使用植物性饲料，并进行了6个月和13个月的随访（6M和13M）。结果包括胃肠道耐受性（GI）、人体测量学指标、肌肉力量和功能（握力、30秒坐立试验（30SCST））、饮食摄入量、每日总饲料量和喂食时间以及安全性。
与患者的基线喂养方案相比，使用植物性饲料的患者报告：在所有时间点胃肠道症状的发生率更低（+7 - 12%，P≤0.04）；胃肠道症状的发生率和严重程度降低：在28D时腹胀、打嗝减少（P<0.05），在13M时便秘、肠胃胀气减少（P<0.05）；在6M至13M期间身体功能有所改善（30SCST重复次数增加2次，P = 0.02），同时体重、小腿围和握力保持稳定；所有时间点的总蛋白摄入量均增加（+0.2 - 0.3克/千克/天，P<0.05）；所有时间点的每日总饲料量（-225至-264毫升/天，P<0.05）和预计泵饲时间（-2小时/天，P<0.05）均减少。
这项纵向研究表明，一种植物性（适合纯素食者）的高能量、高蛋白肠内管饲产品在HETF患者中具有良好的耐受性，对蛋白质摄入有积极的长期影响，并对身体功能有潜在益处。
