Xu Mingxin, Chen Weiyu, Liang Wenjian
Guangzhou University of Chinese Medicine, Guangzhou, China.
The Fifth Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Nutr. 2025 Sep 1;12:1650499. doi: 10.3389/fnut.2025.1650499. eCollection 2025.
Aerobic exercise capacity is a critical determinant of endurance performance and overall health. Natural medicinal plant polysaccharides (NMPPs) have emerged as promising bioagents to enhance aerobic capacity through multi-target mechanisms. This review summarizes the effects of NMPPs on improving aerobic capacity, including oxygen supply and utilization in skeletal muscle, as well as the storage and metabolism of energy substrates. Additionally, we discuss the structural specificity related to their bioactivities. Furthermore, the mechanisms by which NMPPs enhance aerobic capacity encompass anti-fatigue properties, antioxidative effects, anti-inflammatory actions, immunomodulation, and modulation of gut microbiota. However, although there are many evidences, clinical translation requires standardized human trials and deeper exploration of structure-activity relationships. NMPPs represent a safe, multi-mechanistic alternative to conventional strategies, offering novel solutions for improving athletic performance and health resilience.
有氧运动能力是耐力表现和整体健康的关键决定因素。天然药用植物多糖已成为有前景的生物制剂，可通过多靶点机制提高有氧运动能力。本综述总结了天然药用植物多糖对提高有氧运动能力的作用，包括骨骼肌中的氧气供应和利用，以及能量底物的储存和代谢。此外，我们还讨论了与其生物活性相关的结构特异性。此外，天然药用植物多糖提高有氧运动能力的机制包括抗疲劳特性、抗氧化作用、抗炎作用、免疫调节和肠道微生物群调节。然而，尽管有许多证据，但临床转化需要标准化的人体试验和对构效关系的深入探索。天然药用植物多糖是传统策略的一种安全、多机制替代方案，为提高运动表现和健康恢复力提供了新的解决方案。
