Suppr超能文献

弥漫性中线胶质瘤,H3K27改变:一种罕见的表现,具有大脑胶质瘤病生长模式并向中线进展。

Diffuse midline glioma, H3K27-altered: a rare presentation with gliomatosis cerebri growth pattern and progression toward midline.

作者信息

Uchimura Masahiro, Araki Asuka, Eda Hirotake, Kimura Yoriyoshi, Hayashi Kentaro

机构信息

Department of Neurosurgery, NHO Hamada Medical Center, 777-12 Asai-cho, Hamada-shi, Shimane, 697-0022, Japan.

Department of Neurosurgery, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.

出版信息

Brain Tumor Pathol. 2025 Sep 17. doi: 10.1007/s10014-025-00515-1.

Abstract

A limited number of cases involving non-midline lesions have been documented in diffuse midline glioma (DMG), H3K27-altered, for which a definitive classification has yet to be developed. Additionally, no studies have investigated the temporal evolution of imaging features in diffuse non-midline gliomas. We herein report a case of DMG, H3K27-altered, initially presenting with a gliomatosis cerebri-like appearance, cystic lesions in the right frontal lobe, and progression toward the brainstem. Histopathological analysis and comprehensive genomic profiling indicated glioblastoma (GBM) or DMG, H3K27-altered. The patient was diagnosed with GBM because of imaging characteristics atypical for DMG; however, 9 months after the initial diagnosis, a pontine glioma emerged. This case indicates that DMG, H3K27-altered, may exhibit atypical characteristics, including non-midline cystic lesions, that can subsequently progress to pontine gliomas. Considering the limited therapeutic options available for this malignancy, the early recognition of such atypical presentations is crucial for achieving a timely and accurate diagnosis of DMG, H3K27-altered.

摘要

在H3K27改变的弥漫性中线胶质瘤(DMG)中,有少数涉及非中线病变的病例被记录下来,对此尚未形成明确的分类。此外,尚无研究调查弥漫性非中线胶质瘤影像学特征的时间演变情况。我们在此报告一例H3K27改变的DMG病例,该病例最初表现为大脑胶质瘤病样外观、右侧额叶囊性病变,并向脑干进展。组织病理学分析和综合基因组分析表明为胶质母细胞瘤(GBM)或H3K27改变的DMG。由于影像学特征不符合DMG,该患者被诊断为GBM;然而,在初次诊断9个月后,出现了桥脑胶质瘤。该病例表明,H3K27改变的DMG可能表现出非典型特征,包括非中线囊性病变,随后可能进展为桥脑胶质瘤。鉴于针对这种恶性肿瘤的治疗选择有限,早期识别此类非典型表现对于及时、准确诊断H3K27改变的DMG至关重要。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验