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精神分裂症谱系障碍中的体育锻炼疗法:当前证据与治疗建议

Physical exercise therapy in schizophrenia spectrum disorders: current evidence and treatment recommendations.

作者信息

Roell Lukas, Maurus Isabel, Schmitt Andrea, Falkai Peter

机构信息

Department of Psychiatry, Melbourne Neuropsychiatry Centre, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.

Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany.

出版信息

Neuropsychiatr. 2025 Sep 17. doi: 10.1007/s40211-025-00552-4.

DOI:10.1007/s40211-025-00552-4
PMID:40960727
Abstract

Physical exercise has been proposed as an adjunctive treatment for schizophrenia spectrum disorders, with meta-analyses showing benefits for positive, negative, and total symptom severity, as well as cognition and daily functioning, although effects on physical health remain minimal. This narrative review summarizes current evidence, discusses the underlying mechanisms, and offers recommendations for implementing exercise therapy in clinical practice.

摘要

体育锻炼已被提议作为精神分裂症谱系障碍的辅助治疗方法,荟萃分析表明其对阳性、阴性及总体症状严重程度以及认知和日常功能均有益处,尽管对身体健康的影响仍然很小。本叙述性综述总结了当前证据,讨论了潜在机制,并为在临床实践中实施运动疗法提供了建议。

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本文引用的文献

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运动对精神分裂症结构和功能脑模式的影响——一项多中心随机对照研究的数据。
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Schizophr Res. 2023 Jun;256:98-111. doi: 10.1016/j.schres.2023.04.012. Epub 2023 May 18.
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Evaluation of Brain-Body Health in Individuals With Common Neuropsychiatric Disorders.常见神经精神障碍个体的脑-体健康评估。
JAMA Psychiatry. 2023 Jun 1;80(6):567-576. doi: 10.1001/jamapsychiatry.2023.0791.
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Effects of Exercise on Positive Symptoms, Negative Symptoms, and Depression in Patients with Schizophrenia: A Systematic Review and Meta-Analysis.运动对精神分裂症患者阳性症状、阴性症状和抑郁的影响:系统评价和荟萃分析。
Int J Environ Res Public Health. 2023 Feb 20;20(4):3719. doi: 10.3390/ijerph20043719.
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The prognosis of schizophrenia: A systematic review and meta-analysis with meta-regression of 20-year follow-up studies.精神分裂症的预后:一项 20 年随访研究的系统回顾和荟萃分析及荟萃回归。
Schizophr Res. 2022 Dec;250:152-163. doi: 10.1016/j.schres.2022.11.010. Epub 2022 Nov 20.
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Fitness is positively associated with hippocampal formation subfield volumes in schizophrenia: a multiparametric magnetic resonance imaging study.健身与精神分裂症患者海马结构亚区体积呈正相关:一项多参数磁共振成像研究。
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