Wang Zhaowei, Xiao Sufeng, Wan Meiping
Department of Neurology, Qianjiang Central Hospital of Hubei Province, Hubei, China.
Department of Rehabilitation, Qianjiang Central Hospital of Hubei Province, Hubei, China.
PLoS One. 2025 Sep 17;20(9):e0329386. doi: 10.1371/journal.pone.0329386. eCollection 2025.
CSF visinin-like protein 1 (VILIP-1) levels have exhibited potential utility as a marker of neuronal damage and are increased in Alzheimer's disease (AD). The levels of CSF VILIP-1 have been associated with memory decline and hippocampal atrophy, while no studies have investigated the association between CSF VILIP-1 levels and cerebral glucose metabolism among older adults.
Study participants had available baseline CSF VILIP-1 data and more than two assessments of 18-fluorodeoxyglucose positron emission tomography ([18F] FDG-PET) brain imaging. Linear mixed-effects models were used to examine the association between baseline CSF VILIP-1 levels and longitudinal changes in FDG-PET over time. Models were performed separately for the cognitively unimpaired (CU) and cognitively impaired (CI) participants.
Among CU older adults, higher CSF VILIP-1 levels were marginally associated with a faster reduction in cerebral glucose metabolism. In CI older adults, CSF VILIP-1 levels were significantly associated with a faster reduction in cerebral glucose metabolism.
These results provide novel insights into the relationship between neuronal injury and cerebral glucose metabolism, highlighting the potential of CSF VILIP-1 as a biomarker for monitoring and predicting the progression of neurodegenerative processes.
脑脊液中类视锥蛋白 1（VILIP-1）水平已显示出作为神经元损伤标志物的潜在效用，且在阿尔茨海默病（AD）中升高。脑脊液 VILIP-1 水平与记忆衰退和海马萎缩有关，而尚无研究调查老年人脑脊液 VILIP-1 水平与脑葡萄糖代谢之间的关联。
研究参与者有可用的基线脑脊液 VILIP-1 数据以及超过两次的 18-氟脱氧葡萄糖正电子发射断层扫描（[18F] FDG-PET）脑成像评估。使用线性混合效应模型来检查基线脑脊液 VILIP-1 水平与 FDG-PET 随时间的纵向变化之间的关联。分别对认知未受损（CU）和认知受损（CI）参与者进行模型分析。
在 CU 老年人中，较高的脑脊液 VILIP-1 水平与脑葡萄糖代谢更快的降低略有关联。在 CI 老年人中，脑脊液 VILIP-1 水平与脑葡萄糖代谢更快的降低显著相关。
这些结果为神经元损伤与脑葡萄糖代谢之间的关系提供了新的见解，突出了脑脊液 VILIP-1 作为监测和预测神经退行性过程进展的生物标志物的潜力。
