Chen Suling, Ye Xinwu, Wang Qing
Department of Psychiatry, Wenzhou Seventh People's Hospital, No. 158, Xueshiqian, Panqiao Street, Ouhai District, Wenzhou, 325018, China.
Department of Geriatric Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang, China.
Sci Rep. 2025 Jul 10;15(1):24944. doi: 10.1038/s41598-025-08497-y.
Neurogenesis has been implicated in the pathogenesis of Alzheimer's disease (AD). However, the relationship between CSF neurogenin-1 levels and cognitive decline, as well as neurodegeneration in older adults, both with and without cognitive impairment, remains unclear. The current study included 666 individuals, comprising 161 cognitively unimpaired (CU) older adults and 505 cognitively impaired (CI) older adults. To examine the association of CSF neurogenin-1 levels with changes in cognitive performance and neurodegeneration over time, we performed a series of linear mixed-effects models. In these models, baseline CSF neurogenin-1 levels served as the predictor of interest, while cognitive measures, such as Mini-Mental State Examination (MMSE) scores, and hippocampal and ventricular volumes, served as the dependent variables. Higher CSF neurogenin-1 levels were associated with a slower rate of cognitive decline over time in the CI individuals but not in the CU individuals. Regarding structural MRI features, we found that higher baseline CSF neurogenin-1 levels were associated with a slower rate of ventricular enlargement in the CI individuals but not in the CU individuals. No association was observed between CSF neurogenin-1 levels and hippocampal atrophy in either group. Our findings suggest that neurogenin-1 may play a neuroprotective role in CI individuals, potentially slowing cognitive decline and structural brain changes associated with the disease.
神经发生与阿尔茨海默病（AD）的发病机制有关。然而，脑脊液中神经生成素-1水平与认知功能下降以及老年人（无论有无认知障碍）神经退行性变之间的关系仍不清楚。本研究纳入了666名个体，包括161名认知未受损（CU）的老年人和505名认知受损（CI）的老年人。为了研究脑脊液神经生成素-1水平与认知表现变化及神经退行性变随时间的关联，我们进行了一系列线性混合效应模型分析。在这些模型中，脑脊液神经生成素-1的基线水平作为感兴趣的预测因子，而认知测量指标，如简易精神状态检查表（MMSE）得分，以及海马体和脑室体积作为因变量。脑脊液神经生成素-1水平较高与CI个体认知功能随时间下降速度较慢相关，但与CU个体无关。关于结构磁共振成像特征，我们发现脑脊液神经生成素-1的较高基线水平与CI个体脑室扩大速度较慢相关，但与CU个体无关。两组中均未观察到脑脊液神经生成素-1水平与海马体萎缩之间存在关联。我们的研究结果表明，神经生成素-1可能在CI个体中发挥神经保护作用，可能减缓与该疾病相关的认知功能下降和脑结构变化。
