Patata V, Vezzosi T, Fabris C, Bini M, Marchesotti F, Grosso G, Domenech O
Anicura Istituto Veterinario Novara, Strada provinciale 9, 28060, Granozzo con Monticello, Novara, Italy.
Department of Veterinary Sciences, University of Pisa, Via Livornese lato monte, 56122, Pisa, Italy.
J Vet Cardiol. 2025 Aug 21;62:85-93. doi: 10.1016/j.jvc.2025.08.005.
INTRODUCTION/OBJECTIVES: Left atrial dimensions correlate with body weight (BW) in cats. Atrial dimensions can be obtained from both right parasternal long-axis (RPLAx) and right parasternal short-axis images. However, reference ranges for RPLAx-derived left atrial diameter (LAD) obtained from a large sample of healthy cats are needed. This study measured LAD from the RPLAx view and calculated a normalized value to BW (LADn) and left atrial diameter-to-aortic annulus ratio (LAD:Ao). Study aims included developing prediction intervals for LADn, defining reference intervals for LAD:Ao, and investigating useful cutoffs for these variables for detection of congestive heart failure (CHF) in cats with cardiomyopathy.
ANIMALS, MATERIALS AND METHODS: Healthy cats (n = 303) and cats with different types of cardiomyopathy (198 preclinical; 71 with CHF). From RPLAx images, the LAD was measured from the interatrial septum to the free wall at end-systole and aortic diameter was measured at the annulus to calculate the LAD:Ao. Linear regression analysis was used to investigate the effect of BW on the LAD. Cutoffs of LADn and LAD:Ao that identified cats with CHF were generated.
The LAD correlated to BW (r = 0.52, P<0.001). The formula to calculate LADn was LAD (mm)/BW (kg), while median RPLAx LAD:Ao was 2.0 (95% reference interval: 1.55-2.47). Values of LADn >12.7 and LAD:Ao >2.5 had a sensitivity of 92.8% and 88.7% and a specificity of 91.5% and 93.6%, respectively, in detecting CHF.
Due to the retrospective design of the study and lack of longitudinal follow-up, the inclusion of cats with occult CM in the healthy group cannot be entirely ruled out.
The LAD correlates with BW in cats. In the evaluation of LA dimension, LADn and LAD:Ao might be preferable to unadjusted LAD, especially in smaller and larger breeds of cats.
引言/目的：猫的左心房大小与体重（BW）相关。心房大小可从右胸骨旁长轴（RPLAx）和右胸骨旁短轴图像中获取。然而，需要来自大量健康猫样本的RPLAx衍生左心房直径（LAD）的参考范围。本研究从RPLAx视图测量LAD，并计算体重标准化值（LADn）和左心房直径与主动脉环比值（LAD:Ao）。研究目的包括制定LADn的预测区间，定义LAD:Ao的参考区间，并研究这些变量在检测猫心肌病充血性心力衰竭（CHF）时的有用临界值。
动物、材料与方法：健康猫（n = 303）和不同类型心肌病的猫（198例临床前期；71例患有CHF）。从RPLAx图像中，在收缩末期测量从房间隔到游离壁的LAD，并在主动脉环处测量主动脉直径以计算LAD:Ao。采用线性回归分析研究体重对LAD的影响。生成识别患有CHF的猫的LADn和LAD:Ao临界值。
LAD与体重相关（r = 0.52，P<0.001）。计算LADn的公式为LAD（mm）/体重（kg），而RPLAx LAD:Ao的中位数为2.0（95%参考区间：1.55 - 2.47）。在检测CHF时，LADn>12.7和LAD:Ao>2.5的值的敏感性分别为92.8%和88.7%，特异性分别为91.5%和93.6%。
由于研究的回顾性设计以及缺乏纵向随访，不能完全排除健康组中纳入隐匿性心肌病猫的可能性。
猫的LAD与体重相关。在评估左心房大小时，LADn和LAD:Ao可能比未调整的LAD更可取，尤其是在体型较小和较大的猫品种中。
