Katsoudas Sokratis, Umana Luis A, Clarke Rebekah, Thomas Jennifer, Machie Michelle, Angelis Dimitrios
Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Department of Pediatrics, Division of Genetics and Metabolism, University of Texas Southwestern Medical Center, Dallas, TX, USA.
J Perinatol. 2025 Sep 17. doi: 10.1038/s41372-025-02427-6.
The application of ketogenic diet (KD) in newborns is rare and mainly reserved for specific metabolic and seizure disorders. Furthermore, only case reports describe the effects of KD in premature infants. Here, we summarize the recent advances, indications, mechanisms of action and practical issues related to KD. We also provide a paradigm of a preterm male infant born at 34 weeks with pyruvate dehydrogenase deficiency, highlighting the therapeutic challenges and outcomes with the KD. This report underscores the complexities of managing metabolic disorders in neonates and the effects of KD.
生酮饮食（KD）在新生儿中的应用很少见，主要用于特定的代谢和癫痫疾病。此外，仅有病例报告描述了KD在早产儿中的作用。在此，我们总结了与KD相关的最新进展、适应症、作用机制和实际问题。我们还提供了一名34周出生的患有丙酮酸脱氢酶缺乏症的早产男婴的案例，突出了KD治疗的挑战和结果。本报告强调了新生儿代谢紊乱管理的复杂性以及KD的作用。
