Zhou Hong-Yuan, Li Hong, Lu Yu-Jie, Wu Heng-Ping, Li Yong-Zhen
Department of Pathology, The First People's Hospital of Zigong, Zigong, China.
Department of Radiology, The First People's Hospital of Zigong, Zigong, China.
Front Med (Lausanne). 2025 Sep 2;12:1620403. doi: 10.3389/fmed.2025.1620403. eCollection 2025.
Placental transmogrification of the lung (PTL) is an uncommon benign lung lesion characterized by the presence of immature mesenchymal clear cells and frequent cystic changes.
We report two cases. The first case was a 51-year-old woman who presented with chest pain and a history of pulmonary nodule detected during examination for over 1 month. The second case was a 58-year-old man with a smoking history who presented with progressive dyspnea and cough for over 1 month, and was found to have an asymptomatic pulmonary lesion. Computed tomography revealed localized cystic lesions in the first case and bullae in the second. Histological examination showed papillary structures resembling placental villi, lined by cuboidal epithelium without atypia, with hyalinized stromal cores containing capillaries and lymphoplasmacytic infiltration.
PTL exhibits placental-like architecture with CD10-positive stromal cells, suggesting it is a benign mesenchymal tumor rather than a form of emphysema. Pathological confirmation is essential, and surgical resection is the recommended treatment.
肺胎盘样化生（PTL）是一种罕见的良性肺病变，其特征为存在未成熟的间充质透明细胞且常有囊性改变。
我们报告两例病例。第一例为一名51岁女性，因胸痛就诊，在检查中发现肺部结节病史超过1个月。第二例为一名有吸烟史的58岁男性，因进行性呼吸困难和咳嗽超过1个月就诊，发现有一个无症状的肺部病变。计算机断层扫描显示第一例为局限性囊性病变，第二例为肺大疱。组织学检查显示类似胎盘绒毛的乳头状结构，内衬无异型性的立方上皮，透明化的间质核心含有毛细血管及淋巴细胞和浆细胞浸润。
PTL表现出具有CD10阳性间质细胞的胎盘样结构，提示它是一种良性间充质肿瘤而非肺气肿的一种形式。病理确诊至关重要，手术切除是推荐的治疗方法。
