Yang Tianyu, Xu Zhiming, Hu Wentao, Cao Zhifei, Zhang Yongsheng
Department of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou, China.
Dose Response. 2025 Sep 15;23(3):15593258251379921. doi: 10.1177/15593258251379921. eCollection 2025 Jul-Sep.
FLASH radiotherapy (FLASH-RT) is a radiotherapy technique that achieves ultra-high dose rates in a fraction of a second. Based on data from experimental animal models, FLASH-RT appears to protect a number of normal tissues from radiation-induced damage, including the brain, gastrointestinal tract, and lung, while conventional radiotherapy (CONV-RT) causes radiation-induced toxicity in these tissues. In this review, we provide a brief summary of the history of radiation therapy and focus on some of the most recent FLASH-RT papers and findings. It is particularly noteworthy that pulmonary fibrosis represents a common complication of radiotherapy. New evidence indicates that FLASH-RT, unlike traditional radiotherapy methods, might help protect lung cancer patients from developing pulmonary fibrosis caused by radiation. FLASH-RT will advance more quickly than anticipated, although there are still a number of unresolved concerns. FLASH-RT will be a safer and more effective option for lung cancer treatment.
闪速放疗（FLASH-RT）是一种能在几分之一秒内实现超高剂量率的放疗技术。基于实验动物模型的数据，FLASH-RT似乎能保护多种正常组织免受辐射诱导的损伤，包括脑、胃肠道和肺，而传统放疗（CONV-RT）会在这些组织中导致辐射诱导的毒性。在本综述中，我们简要概述了放射治疗的历史，并重点关注一些最新的FLASH-RT论文和研究结果。特别值得注意的是，肺纤维化是放疗的常见并发症。新证据表明，与传统放疗方法不同，FLASH-RT可能有助于保护肺癌患者免受辐射引起的肺纤维化。尽管仍有一些未解决的问题，但FLASH-RT的进展将比预期更快。对于肺癌治疗，FLASH-RT将是一种更安全、更有效的选择。
