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乳腺上皮-肌上皮癌能否从TROP2抗体药物偶联物中获益？

Can Epithelial-Myoepithelial Carcinoma of the Breast Benefit from TROP2 Antibody-Drug Conjugate?

作者信息

Zhao Qing, Luo Xiao, Xing Hua, Jiang Chengwei, Ma Jingchao, Tang Lu

机构信息

Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, People's Republic of China.

Department of Pathology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, People's Republic of China.

出版信息

Onco Targets Ther. 2025 Sep 12;18:1013-1025. doi: 10.2147/OTT.S540295. eCollection 2025.

DOI:10.2147/OTT.S540295
PMID:40963786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12439690/
Abstract

Epithelial-myoepithelial carcinoma (EMC) of the breast is a rare biphasic tumor composed of intermixed malignant epithelial and myoepithelial components. Breast epithelial myoepithelial carcinoma lacks therapeutic strategies due to its rarity, and currently local treatment is still the main treatment. Herein we report an epithelial-myoepithelial carcinoma of the breast in a 33-year-old woman undergoing breast conserving surgery, sentinel lymph node biopsy, adjuvant chemotherapy and radiotherapy, with rapid liver and lung metastasis. After radiofrequency ablation therapy for metastatic lesions, vinorelbine plus cisplatin and TROP2 antibody-drug conjugate (ADC) treatment were given successively. After a brief improvement, drug resistance developed and the disease progressed. The patient died with the PFS 5.6 months.

摘要

乳腺上皮-肌上皮癌（EMC）是一种罕见的双相性肿瘤，由恶性上皮成分和肌上皮成分混合组成。乳腺上皮-肌上皮癌由于其罕见性而缺乏治疗策略，目前局部治疗仍是主要治疗方法。在此，我们报告一例33岁接受保乳手术、前哨淋巴结活检、辅助化疗和放疗的乳腺上皮-肌上皮癌患者，其出现快速的肝肺转移。在对转移灶进行射频消融治疗后，先后给予长春瑞滨联合顺铂及TROP2抗体药物偶联物（ADC）治疗。短暂改善后出现耐药，疾病进展。患者死亡，无进展生存期为5.6个月。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/12439690/a956a3a6d0ee/OTT-18-1013-g0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/12439690/2e7389465ec3/OTT-18-1013-g0006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/12439690/a956a3a6d0ee/OTT-18-1013-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/12439690/a63ed18e1582/OTT-18-1013-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/12439690/8c44016d8c06/OTT-18-1013-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/12439690/5d9b03b522e6/OTT-18-1013-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/12439690/6714ccb830ca/OTT-18-1013-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/12439690/fae06a55cc82/OTT-18-1013-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/12439690/2e7389465ec3/OTT-18-1013-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/12439690/c73cc55ab95c/OTT-18-1013-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e23/12439690/a956a3a6d0ee/OTT-18-1013-g0008.jpg

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本文引用的文献

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Clin Breast Cancer. 2025 Jul;25(5):e511-e516.e8. doi: 10.1016/j.clbc.2025.01.012. Epub 2025 Jan 25.
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Malignant breast adenomyoepithelioma: case report and literature review.恶性乳腺腺肌上皮瘤：病例报告及文献复习
Front Med (Lausanne). 2025 Jan 15;11:1525050. doi: 10.3389/fmed.2024.1525050. eCollection 2024.
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ADENOMYOEPITHELIOMA WITH CARCINOMA; EPITHELIAL-MYOEPITHELIAL CARCINOMA WITH EARLY PULMONARY METASTASIS.
伴有癌的腺肌上皮瘤；伴有早期肺转移的上皮-肌上皮癌
J Ayub Med Coll Abbottabad. 2024 Jul-Sep;36(3):667-669. doi: 10.55519/JAMC-03-13011.
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Malignant Adenomyoepithelioma of the Breast.乳腺恶性腺肌上皮瘤
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Datopotamab Deruxtecan Versus Chemotherapy in Previously Treated Inoperable/Metastatic Hormone Receptor-Positive Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer: Primary Results From TROPION-Breast01.达泊托单抗德鲁替康与化疗用于既往治疗过的不可切除/转移性激素受体阳性、人表皮生长因子受体2阴性乳腺癌的疗效比较：TROPION-Breast01研究的主要结果
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Malignant adenomyoepithelioma of the breast in a male patient: A case report.男性患者乳腺恶性腺肌上皮瘤：一例报告
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Malignant adenomyoepithelioma of the breast: Case report.乳腺恶性腺肌上皮瘤：病例报告
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