Zhang Yuanyuan, Zhang Xuerong, Xie Zhenrong, Xiong Jingjing, Li Meng, Li Zhanhua, Huang Yongkun
Department of Pediatrics The First Affiliated Hospital of Kunming Medical University Kunming China.
Department of Scientific Research and Education The First Affiliated Hospital of Kunming Medical University Kunming China.
Food Sci Nutr. 2025 Sep 15;13(9):e70922. doi: 10.1002/fsn3.70922. eCollection 2025 Sep.
The vitamins in infants who are exclusively breastfed before 6 months of age mainly come from breastfeeding. Whether or not dynamic vitamin concentrations in human milk were affected by maternal factors and their roles in infant growth and diseases has yet to be determined. Using data from a tertiary hospital for 46 couples of fit mothers and infants aged 1 to 3 months in China, we collected mothers' human milk as samples for UPLC-MS/MS sequencing evaluation of vitamins. Multiple regression and binomial logistic regression were used in analyses that controlled for confounding. The content of vitamin B1 was significantly higher at 105 to 119 days postpartum than it was at 30 to 44 days after delivery ( < 0.05). Additionally, vitamin C was related to infant weight-for-age ( = 0.05, SE = 0.02, = 0.02). Vitamins C ( = 0.00015, SE = 0.00006, = 0.01) and B7 ( = 0.00048, SE = 0.00023, = 0.04) were related to infant BMI. After adjustment for sample collection times, vitamins A and B1, the odds ratio for vitamin K in the BMJ group was 13.93 (95% CI, 0.93 to 208.48, = 0.05). Overall, the vitamin B1 contents from human milk change in different stages of lactation. A longer duration of fully breastfeeding with vitamins B7 and C provides better developmental nutrients to infants aged 1 to 3 months. According to our study, vitamin K concentration seems to be increased in the human milk of mothers whose infants had BMJ. This trial was registered on 22/12/2023 as ChiCTR2300078973.
6个月龄前纯母乳喂养婴儿的维生素主要来源于母乳。母乳中维生素的动态浓度是否受母体因素影响及其在婴儿生长和疾病中的作用尚待确定。利用中国一家三级医院46对健康母婴（母亲和1至3个月龄婴儿）的数据，我们收集母亲的母乳作为样本，用于维生素的超高效液相色谱-串联质谱（UPLC-MS/MS）测序评估。分析中采用多元回归和二项逻辑回归来控制混杂因素。产后105至119天母乳中维生素B1的含量显著高于分娩后30至44天（P<0.05）。此外，维生素C与婴儿年龄别体重相关（β = 0.05，标准误 = 0.02，P = 0.02）。维生素C（β = 0.00015，标准误 = 0.00006，P = 0.01）和B7（β = 0.00048，标准误 = 0.00023，P = 0.04）与婴儿体重指数相关。在调整样本采集时间、维生素A和B1后，BMJ组中维生素K的优势比为13.93（95%可信区间，0.93至208.48，P = 0.05）。总体而言，母乳中维生素B1的含量在哺乳期不同阶段有所变化。维生素B7和C的全母乳喂养时间越长，为1至3个月龄婴儿提供的发育营养越好。根据我们的研究，婴儿患有BMJ的母亲的母乳中维生素K浓度似乎会升高。本试验于2023年12月22日注册，注册号为ChiCTR2300078973。
