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揭开谜团:当代研究中探索睡眠、免疫系统与姜黄素之间的动态相互作用

Unlocking Mysteries: Exploring the Dynamic Interplay Among Sleep, the Immune System, and Curcumin in Contemporary Research.

作者信息

Kumar Rohit, Pandey Atul, Vibhuti Arpana, Ali Manzoor, Chang Chung-Ming, Pandey Ramendra Pati

机构信息

Department of Biotechnology, Sri Ramaswamy Memorial (SRM) University, Sonipat, Haryana, India.

Department of Ecology and Evolutionary Biology, College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI, United States.

出版信息

Sleep Sci. 2025 Mar 27;18(3):e336-e346. doi: 10.1055/s-0045-1802321. eCollection 2025 Sep.

Abstract

The scientific disciplines encompassing sleep, the immune system, and curcumin have garnered considerable interest due to their interconnectedness and potential implications for human health. Sleep is a crucial factor in maintaining optimal immune function, as it facilitates the release of cytokines, which are signaling molecules responsible for regulating immune responses. On the contrary, sleep deprivation has the potential of inhibiting immune function, thereby heightening the susceptibility to infection and disease. Curcumin, a naturally occurring polyphenol derived from the turmeric plant, has been observed to possess immunomodulatory characteristics through its ability to modulate the equilibrium between pro- and anti-inflammatory cytokines. It is worth noting that there is evidence suggesting that curcumin supplementation could enhance the quality of sleep. Scientific studies have indicated that curcumin supplementation has been associated with an increase in the duration of sleep and a decrease in wakefulness among individuals who are in good health. Additionally, curcumin supplementation has been found to enhance sleep quality and alleviate symptoms of depression in individuals diagnosed with major depressive disorder. The intricate interplay among sleep, the immune system, and curcumin is multifaceted, and scientific investigations indicate that curcumin may serve as a beneficial dietary adjunct to enhance immune function and optimize sleep quality. Nevertheless, additional investigation is required to fully comprehend the mechanisms through which curcumin alters the immune system and enhances sleep, as well as to ascertain the most effective dose and timing of curcumin supplementation.

摘要

涵盖睡眠、免疫系统和姜黄素的科学学科因其相互关联性以及对人类健康的潜在影响而备受关注。睡眠是维持最佳免疫功能的关键因素,因为它有助于细胞因子的释放,细胞因子是负责调节免疫反应的信号分子。相反,睡眠剥夺有可能抑制免疫功能,从而增加感染和患病的易感性。姜黄素是一种从姜黄植物中提取的天然多酚,通过调节促炎和抗炎细胞因子之间的平衡,已被观察到具有免疫调节特性。值得注意的是,有证据表明补充姜黄素可以提高睡眠质量。科学研究表明,补充姜黄素与健康个体睡眠时间的增加和清醒时间的减少有关。此外,已发现补充姜黄素可提高被诊断患有重度抑郁症个体的睡眠质量并减轻抑郁症状。睡眠、免疫系统和姜黄素之间复杂的相互作用是多方面的,科学研究表明姜黄素可能作为一种有益的饮食辅助手段来增强免疫功能并优化睡眠质量。然而,需要进一步研究以充分理解姜黄素改变免疫系统和改善睡眠的机制,以及确定补充姜黄素的最有效剂量和时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9355/12440604/7e9476a69736/10-1055-s-0045-1802321-i240132-1.jpg

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