Shojaei Mehrnaz, Sahebkar Amirhossein, Khorvash Fariborz, Fallahpour Soheil, Askari Gholamreza, Bagherniya Mohammad
Student Research Committee, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Avicenna J Phytomed. 2023 Jan-Feb;13(1):45-57. doi: 10.22038/AJP.2022.21242.
Migraine is one of the most common diseases. Curcumin with anti-oxidative and anti-neuroinflammatory properties might have beneficial effects in migraine patients. This study will be conducted to evaluate the effects of a phytosomal preparation of curcumin on clinical signs, oxidative stress, and inflammatory parameters in patients with migraine.
This is a randomized, double-blind, placebo-controlled, clinical trial in which, 60 patients with migraine will be assigned to receive a daily dose of 250 mg of phytosomal curcumin for 8 weeks (intervention group) or 250 mg maltodextrin as a placebo for the same duration (control group). Before and after the study, frequency, duration, and severity of the attacks, quality of life and sleep, mood status, high-sensitivity C-reactive protein (hs-CRP), Nitric Oxide (NO), and oxidative stress factors will be measured.
It seems that phytosomal formulation of curcumin (a solid dispersion preparation of curcumin with phosphatidylserine) with high bioavailability, can cross the blood-brain barrier (BBB) and result in decreased neuroinflammation, oxidative stress, and neurotoxicity. This way, phytosomal curcumin might lead to reduction of headaches and other complications of migraine and increase the quality of life of patients with migraine.
偏头痛是最常见的疾病之一。具有抗氧化和抗神经炎症特性的姜黄素可能对偏头痛患者有益。本研究旨在评估姜黄素的植物药制剂对偏头痛患者临床症状、氧化应激和炎症参数的影响。
这是一项随机、双盲、安慰剂对照的临床试验，60例偏头痛患者将被分配接受每日剂量250毫克的姜黄素植物药制剂，持续8周（干预组），或同样持续时间每日服用250毫克麦芽糊精作为安慰剂（对照组）。在研究前后，将测量发作的频率、持续时间和严重程度、生活质量和睡眠、情绪状态、高敏C反应蛋白（hs-CRP）、一氧化氮（NO）和氧化应激因素。
姜黄素的植物药制剂（姜黄素与磷脂酰丝氨酸的固体分散体制剂）似乎具有高生物利用度，可穿过血脑屏障（BBB），并导致神经炎症、氧化应激和神经毒性降低。通过这种方式，姜黄素植物药可能会减少偏头痛的头痛及其他并发症，并提高偏头痛患者的生活质量。
