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使阿巴拉契亚地区的阿片类药物和解支出与证据及新出现的威胁保持一致。

Align Appalachia's Opioid-Settlement Spending with Evidence and Emerging Threats.

作者信息

Firchow Bradley

机构信息

University of Kentucky.

出版信息

J Appalach Health. 2025 Sep 1;7(3):1-5. doi: 10.13023/jah.0703.01. eCollection 2025.

DOI:10.13023/jah.0703.01
PMID:40964416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12440308/
Abstract

State and local governments across Appalachia are allocating opioid-settlement dollars over the coming years. This funding opportunity can support lasting public health infrastructure or be spent on short-term programs anchored in the opioid crisis of the past. Evidence indicates that emerging synthetic drugs such as nitazenes and xylazine are altering overdose risk patterns in ways that require urgent policy attention.

摘要

阿巴拉契亚地区的州和地方政府在未来几年将分配阿片类药物和解资金。这个资金机会可以支持持久的公共卫生基础设施,也可以用于过去阿片类药物危机相关的短期项目。有证据表明,诸如硝氮烯和赛拉嗪等新兴合成药物正在改变过量用药风险模式,这需要政策给予紧急关注。

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本文引用的文献

1
Community-based drug checking at syringe service programs in New York City observe an increasing prevalence of xylazine from 2021 through 2024.纽约市注射器服务项目中基于社区的药物检测发现,从2021年到2024年,赛拉嗪的流行率呈上升趋势。
Harm Reduct J. 2025 Jun 7;22(1):99. doi: 10.1186/s12954-025-01237-5.
2
Nitazenes: review of comparative pharmacology and antagonist action.硝氮烯类:比较药理学与拮抗作用综述
Clin Toxicol (Phila). 2025 Jun;63(6):393-406. doi: 10.1080/15563650.2025.2504133. Epub 2025 May 27.
3
Fentanyl Test Strip Use and Overdose Risk Reduction Behaviors Among People Who Use Drugs.吸毒者中芬太尼试纸的使用及过量用药风险降低行为
JAMA Netw Open. 2025 May 1;8(5):e2510077. doi: 10.1001/jamanetworkopen.2025.10077.
4
Public health impact and harm reduction implications of xylazine-involved overdoses: a narrative review.涉及苯环己哌啶的药物过量对公共卫生的影响和减少危害的作用:叙事性综述。
Harm Reduct J. 2023 Sep 12;20(1):131. doi: 10.1186/s12954-023-00867-x.
5
Xylazine in the drug supply: Emerging threats and lessons learned in areas with high levels of adulteration.药品供应中的赛拉嗪:掺假率高的地区出现的新威胁及经验教训
Int J Drug Policy. 2023 Oct;120:104154. doi: 10.1016/j.drugpo.2023.104154. Epub 2023 Aug 11.
6
Old Drugs and New Challenges: A Narrative Review of Nitazenes.老药与新挑战:硝氮烯类药物的叙述性综述
Cureus. 2023 Jun 21;15(6):e40736. doi: 10.7759/cureus.40736. eCollection 2023 Jun.
7
Notes from the Field: Nitazene-Related Deaths - Tennessee, 2019-2021.实地记录:与硝氮烯相关的死亡事件——田纳西州,2019年至2021年
MMWR Morb Mortal Wkly Rep. 2022 Sep 16;71(37):1196-1197. doi: 10.15585/mmwr.mm7137a5.