Maleville J, Taïeb A, Roubaud E, Sarrat P, Fontan I, Guillet G
Ann Dermatol Venereol. 1985;112(8):603-8.
The purpose of this study was to determine the course of cutaneous immature angiomas in a population of 362 children examined in a pediatric dermatology unit from 1975 to 1982. 461 angiomas were observed in these patients: 110 were of the naevus flammaeus type (port wine stain) including 23 forehead salmon patches. 351 were immature angiomas (IA)--strawberry angiomas. 3.5 p. 100 of children were afflicted of two types of hemangiomas. Results concerning the 282 patients with 351 IA are detailed as followed: average follow-up: 2 years; sex-ratio M/S 1.9, most of them Caucasians. Prematurity (data obtained prospectively during 1982): 19 p. 100; clinical features: dermal: 253, subcutaneous: 35, mixed pattern 63; 2 IA or more were detected in 12 p. 100 of the patients; site: head and neck; 49 p. 100, trunk: 21 p. 100, upper limbs: 14.5 lower limbs: 12 p. 100, genitals 3.5 p. 100; maximal size during follow-up: less than 1 cm: 36 p. 100, between 1 and 3 cm: 43 p. 100, more than 3 cm; 21 p. 100; time of onset: 51 p. 100 were noted at birth, 35 p. 100 during the first month, 13 p. 100 after the first month. Course of untreated IA is shown in figure 1. At the end of follow-up, spontaneous evolution in 52 patients was judged; very good in 44 p. 100, good in 41 p. 100, poor or bad in 15 p. 100. Minor complications (ulceration, infection, bleeding) were observed in 12.8 p. 100. Functional impairment requiring therapy was present in 2/4 plantar IA, 3/30 eyelid IA, 3/3 IA with laryngeal involvement.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究的目的是确定1975年至1982年在一家儿科皮肤科接受检查的362名儿童中皮肤未成熟血管瘤的病程。在这些患者中观察到461个血管瘤：110个为鲜红斑痣型（葡萄酒色斑），包括23个前额鲑鱼斑。351个是未成熟血管瘤（IA）——草莓状血管瘤。每100名儿童中有3.5名患有两种类型的血管瘤。关于282名患有351个IA的患者的结果详细如下：平均随访时间：2年；男女比例为1.9，大多数为白种人。早产（1982年前瞻性获得的数据）：每100名中有19名；临床特征：真皮型：253个，皮下型：35个，混合型63个；每100名患者中有12名检测到2个或更多IA；部位：头颈部：每100名中有49个，躯干：每100名中有21个，上肢：14.5个，下肢：每100名中有12个，生殖器：每100名中有3.5个；随访期间最大尺寸：小于1厘米：每100名中有36个，1至3厘米：每100名中有43个，大于3厘米：每100名中有21个；发病时间：每100名中有51个在出生时被注意到，每100名中有35个在第一个月内，每100名中有13个在第一个月后。未治疗的IA的病程见图1。在随访结束时，对52名患者的自发演变进行了评估；每100名中有44名非常好，每100名中有41名良好，每100名中有15名差或不良。每100名中有12.8名观察到轻微并发症（溃疡、感染、出血）。2/4例足底IA、3/30例眼睑IA、3/3例伴有喉部受累的IA存在需要治疗的功能障碍。（摘要截断于250字）
