Getachew Minale, Tora Ephrem, Mohammed Nejib, Benti Teferi
Arba Minch University, Arba Minch, South Ethiopia, Ethiopia.
Animal Health Institute, Sebeta, Ethiopia.
Immun Inflamm Dis. 2025 Sep;13(9):e70257. doi: 10.1002/iid3.70257.
Mycoplasma capricolum subspecies capripneumoniae is the causative agent of contagious caprine pleuropneumonia (CCPP), a highly infectious and economically significant disease affecting goats and sheep. CCPP is characterized by high morbidity and mortality rates, leading to substantial financial losses in affected regions. The aim of this study was to estimate seroprevalence and pinpoint risk factors for the occurrence of CCPP in the study area.
A cross-sectional study employing a multistage cluster sampling technique was carried out in the Derashe zone in 2021. In the study area, 426 goats from six villages and three clusters were tested for CCPP serostatus using the Competitive Enzyme-Linked Immunosorbent Assay (c-ELISA). Goat level CCPP was predicted by a mixed-effect logistic regression model, while flock level CCPP was tested for association with risk factors using Chi-square test.
Serum sample results revealed a 4.7% seroprevalence at the goat level (95% CI: 2.9-7.6), and a 52% prevalence at the flock level (95% CI: 31.3-72.2). The presence of health problems were associated with 4.2 times greater odds of CCPP seropositivity than those without health problems (OR = 4.2; p = 0.000). Goats found in large flock sizes were 5.7 times more likely to suffer a CCPP seropositivity than small flock sized goats owned together (OR = 5.7; p = 0.009).
Given that the Derashe zone serves as a key livestock movement corridor with goats frequently transported to central regions of Ethiopia, and that contagious caprine pleuropneumonia demonstrated a high flock-level prevalence across all study villages and clusters, it is crucial to implement a routine vaccination program to effectively control the disease.
山羊支原体山羊肺炎亚种是山羊传染性胸膜肺炎（CCPP）的病原体，CCPP是一种对山羊和绵羊具有高度传染性且在经济上具有重要影响的疾病。CCPP的特点是发病率和死亡率高，给受影响地区造成重大经济损失。本研究的目的是估计研究区域内CCPP的血清流行率并确定其发生的风险因素。
2021年在德拉谢地区采用多阶段整群抽样技术进行了一项横断面研究。在研究区域，使用竞争酶联免疫吸附测定法（c-ELISA）对来自六个村庄和三个群组的426只山羊进行了CCPP血清状态检测。通过混合效应逻辑回归模型预测山羊水平的CCPP，而使用卡方检验检测群组水平的CCPP与风险因素的关联。
血清样本结果显示，山羊水平的血清流行率为4.7%（95%置信区间：2.9 - 7.6），群组水平的流行率为52%（95%置信区间：31.3 - 72.2）。有健康问题的山羊CCPP血清阳性几率比没有健康问题的山羊高4.2倍（比值比 = 4.2；p = 0.000）。大群规模的山羊CCPP血清阳性的可能性是一起饲养的小群规模山羊的5.7倍（比值比 = 5.7；p = 0.009）。
鉴于德拉谢地区是重要的牲畜移动走廊，山羊经常被运往埃塞俄比亚中部地区，且传染性山羊胸膜肺炎在所有研究村庄和群组中都显示出较高的群组水平流行率，实施常规疫苗接种计划以有效控制该疾病至关重要。
