Laumonier R, Roussel F, Halkin E, Delapierre F
Ann Gastroenterol Hepatol (Paris). 1985 Dec;21(6):401-8.
An experimental model of colonic cancer can be obtained in rodents by administration of 1-2 Dimethylhydrazine. It produces constant, reproducible lesions, ranging from simple anomalies of secretion to invasive cancers, which are identical to those observed in man. It should be noted that the rats and mice used in these experiments do not present spontaneous colonic tumours. This model has contributed to the substitution of the polyp-cancer sequence by the dysplasia-cancer sequence. All of steps of malignant transformation of the mucosa can be followed by histochemistry of the mucins, by ultrastructural examination of the basement membrane and by labeling of the sub-epithelial connective tissue with hyaluronectin. In man, it is possible to define high risk lesions prior to the appearance of polyps.
通过给予1,2 - 二甲基肼，可在啮齿动物中获得结肠癌实验模型。它会产生持续且可重复的病变，从简单的分泌异常到侵袭性癌症，这些病变与在人类中观察到的病变相同。应当指出的是，这些实验中使用的大鼠和小鼠不会出现自发性结肠肿瘤。该模型促使息肉 - 癌序列被发育异常 - 癌序列所取代。黏膜恶性转化的所有步骤都可以通过黏蛋白的组织化学、基底膜的超微结构检查以及用透明质酸结合素标记上皮下结缔组织来追踪。在人类中，在息肉出现之前就有可能确定高风险病变。
