Chen Jiani, Zhang Chen, Zhang Qianqian, Cheng Fuying, Wang Yizhang, Xue Shirui, Yang Yufei, Guo Wenwen, Liu Juan, Xue Kai, Zhang Yaguang, Wang Dehui, Hu Li, Wang Huan, Sun Xicai
High Altitude Rhinology Research Center, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital of Fudan University, Shanghai, 200031, China.
Clin Rev Allergy Immunol. 2025 Sep 18;68(1):87. doi: 10.1007/s12016-025-09097-4.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common upper airway inflammatory disorder, characterized by persistent inflammation of the sinonasal mucosa and nasal polyp formation. The pivotal roles of interleukin (IL)-4/IL-13 signaling in CRSwNP pathogenesis is increasingly recognized, evidenced by the remarkable clinical success of biologics targeting this pathway. This review provides a concise overview of the IL-4/IL-13 pathway in CRSwNP, encompassing its molecular architecture, pathogenic mechanisms, current targeted therapies, and emerging therapeutic strategies.
伴鼻息肉的慢性鼻-鼻窦炎（CRSwNP）是一种常见的上气道炎症性疾病，其特征为鼻窦黏膜持续炎症和鼻息肉形成。白细胞介素（IL）-4/IL-13信号传导在CRSwNP发病机制中的关键作用日益受到认可，针对该通路的生物制剂取得显著临床疗效即为明证。本文综述简要概述了CRSwNP中IL-4/IL-13通路，包括其分子结构、致病机制、当前的靶向治疗以及新兴治疗策略。
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