Huang T F, Yang B B
Arch Int Pharmacodyn Ther. 1985 Nov;278(1):128-41.
The ventricular fibrillation threshold (VFT) was determined by the electrical stimulation of the normal and the coronary artery-ligated myocardium in situ in anesthetized rats. A bilateral vagotomy lowered the VFT of the normal myocardium. After the coronary artery ligation in the vagotomized rats, VFT fell to a greater extent. Bretylium 20-40 mg/kg i.v. produced an elevation of VFT, hypotension and a decrease of the heart rate of rats with the normal or the ischemic myocardium. Lidocaine 10 mg/kg i.v. insignificantly affected the VFT of the normal and the ischemic myocardium. Nitroprusside 4 mg/kg i.v. elevated the VFT of the normal myocardium, and prevented a fall in the VFT of the ischemic myocardium. Adenosine 10 mg/kg or aspirin 20 mg/kg i.v. had no remarkable effect on the VFT of the normal myocardium, but prevented a fall in the VFT of the ischemic myocardium.
通过对麻醉大鼠正常心肌和冠状动脉结扎心肌进行原位电刺激来测定心室颤动阈值（VFT）。双侧迷走神经切断术降低了正常心肌的VFT。在迷走神经切断的大鼠冠状动脉结扎后，VFT下降幅度更大。静脉注射20 - 40 mg/kg的溴苄铵可使正常或缺血心肌大鼠的VFT升高、血压降低并使心率下降。静脉注射10 mg/kg的利多卡因对正常和缺血心肌的VFT影响不显著。静脉注射4 mg/kg的硝普钠可提高正常心肌的VFT，并防止缺血心肌的VFT下降。静脉注射10 mg/kg的腺苷或20 mg/kg的阿司匹林对正常心肌的VFT没有显著影响，但可防止缺血心肌的VFT下降。
