Arbel E R, Glick G
J Pharmacol Exp Ther. 1979 Feb;208(2):314-8.
The present work studied the effect of veratrine on electrical stability of the mammalian ventricles. In a group of anesthetized open-chest dogs we determined the effects of veratrine (0.001-0.3 mg/kg) on the threshold for ventricular fibrillation (VFT), both during sinus rhythm (SR) and during atrial drive (AD) at 166 +/- 7 beats/min. Veratrine (0.3 mg/kg) increased the VFT during SR from control levels of 33 +/- 5 mA to 56 +/- 4 mA (P less than .05) and during AD from 34 +/- 6 to 57 +/- 9 mA (P less than .05). VFTs after infusion of veratrine were higher than in a control group of dogs given the saline diluent in which VFT during SR was 26 +/- 3 mA (P less than .001) and during AD was 24 +/- 3 mA (P less than .005). The increase in VFT during SR was independent of the decrease in heart rate, which fell from 147 +/- 8 to 106 +/- 6 beats/min (P less than .001). It was associated, however, with an increase in the QT interval during SR from control values of 254 +/- 13 to 308 +/- 19 msec (P less than .02) and during AD from 238 +/- 8 to 267 +/- 8 msec (P less than .005). We conclude that small doses of veratrine increase the electrical stability of the ventricles in the normal dog heart.
本研究探讨了藜芦碱对哺乳动物心室电稳定性的影响。在一组麻醉开胸犬中，我们测定了藜芦碱（0.001 - 0.3 mg/kg）在窦性心律（SR）期间以及在166±7次/分钟的心房驱动（AD）期间对室颤阈值（VFT）的影响。藜芦碱（0.3 mg/kg）使SR期间的VFT从对照水平的33±5 mA增加到56±4 mA（P <.05），AD期间从34±6 mA增加到57±9 mA（P <.05）。输注藜芦碱后的VFT高于给予生理盐水稀释剂的对照组犬，该对照组犬SR期间的VFT为26±3 mA（P <.001），AD期间为24±3 mA（P <.005）。SR期间VFT的增加与心率下降无关，心率从147±8次/分钟降至106±6次/分钟（P <.001）。然而，它与SR期间QT间期从对照值254±13毫秒增加到308±19毫秒（P <.02）以及AD期间从238±8毫秒增加到267±8毫秒（P <.005）有关。我们得出结论，小剂量藜芦碱可增加正常犬心脏心室的电稳定性。
