Lauria Jacopo, Zappalà Giulio, Sidoti Flavio Calogero, Scarpelli Gianluca, Greco Antonio, Andracchio Vincenzo, Chiaradia Francesco, Vitarelli Antonio, Alba Stefano
Unit of Urology, Romolo Hospital SRL, Rocca di Neto, KR, Italy.
Mater Dei Hospital, Bari, Italy.
Int J Impot Res. 2025 Sep 18. doi: 10.1038/s41443-025-01169-5.
Paraffinoma of the penis is a rare but potentially debilitating consequence of subcutaneous mineral-oil injection for penile enlargement. We report a 34-year-old male who presented after failed urethral catheterization with diffuse penile induration and pain during intercourse, following self-injection of paraffin into the preputial region. Clinical assessment and penile ultrasound with color Doppler supported the diagnosis; histology confirmed sclerosing lipogranuloma without malignancy. The patient underwent complete degloving, radical excision of infiltrated tissues, and reconstruction using full-thickness skin grafts harvested from the right biceps and left thigh. Postoperative care included compression dressings and targeted antibiotics, with satisfactory graft take and acceptable cosmetic outcome at 10 and 40 days. Persistent dissatisfaction with penile size highlighted the need for integrated psychological assessment alongside surgical management.