Chen Wei, Liu Peng
State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
School of Chemistry and Chemical Engineering, Qinghai Normal University, Xining, 810016, China.
Mikrochim Acta. 2025 Sep 18;192(10):678. doi: 10.1007/s00604-025-07546-7.
Dendritic polymer-based unimolecular micelles have attracted more interest in tumor chemotherapy. However, the drug release behavior was significantly affected by the hydrophilic-hydrophobic property of the dendritic cores. In the present work, carbon quantum dot (CQD) was used as a bridge between the dendritic core and drug to achieve a better drug release performance for imaging-mediated therapy. Strawberry-shaped hybrid prodrug was designed with a DOX content of 16.7%. The resultant hybrid unimolecular micelles with a mean hydrodynamic diameter of around 82 nm showed sustained acid-triggered DOX release with minimized drug leakage, possessing enhanced anti-tumor efficacy compared to free DOX. Furthermore, the fluorescence of the hybrid unimolecular micelles could be turned on for imaging-guided cancer therapy after tumor intracellular drug release.
基于树枝状聚合物的单分子胶束在肿瘤化疗中引起了更多关注。然而，树枝状核的亲水-疏水性质显著影响药物释放行为。在本研究中，碳量子点（CQD）被用作树枝状核与药物之间的桥梁，以实现成像介导治疗中更好的药物释放性能。设计了草莓状杂合前药，阿霉素含量为16.7%。所得平均流体动力学直径约为82 nm的杂合单分子胶束表现出持续的酸触发阿霉素释放，药物泄漏最小化，与游离阿霉素相比具有增强的抗肿瘤疗效。此外，在肿瘤细胞内药物释放后，杂合单分子胶束的荧光可以开启用于成像引导的癌症治疗。
