Department of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha St., 02-097 Warsaw, Poland.
Military Institute of Hygiene and Epidemiology, 4 Kozielska St., 01-163 Warsaw, Poland.
Int J Mol Sci. 2022 Jul 25;23(15):8181. doi: 10.3390/ijms23158181.
With the intensive development of polymeric biomaterials in recent years, research using drug delivery systems (DDSs) has become an essential strategy for cancer therapy. Various DDSs are expected to have more advantages in anti-neoplastic effects, including easy preparation, high pharmacology efficiency, low toxicity, tumor-targeting ability, and high drug-controlled release. Polyurethanes (PUs) are a very important kind of polymers widely used in medicine, pharmacy, and biomaterial engineering. Biodegradable and non-biodegradable PUs are a significant group of these biomaterials. PUs can be synthesized by adequately selecting building blocks (a polyol, a di- or multi-isocyanate, and a chain extender) with suitable physicochemical and biological properties for applications in anti-cancer DDSs technology. Currently, there are few comprehensive reports on a summary of polyurethane DDSs (PU-DDSs) applied for tumor therapy. This study reviewed state-of-the-art PUs designed for anti-cancer PU-DDSs. We studied successful applications and prospects for further development of effective methods for obtaining PUs as biomaterials for oncology.
近年来，随着聚合生物材料的深入发展，利用药物传递系统（DDS）的研究已成为癌症治疗的重要策略。各种 DDS 有望在抗肿瘤作用方面具有更多优势，包括易于制备、高药效效率、低毒性、肿瘤靶向能力和高药物控制释放。聚氨酯（PU）是一种在医学、药学和生物材料工程中广泛使用的非常重要的聚合物。可生物降解和不可生物降解的 PU 是这些生物材料中的重要一类。通过适当选择具有合适物理化学和生物特性的构建块（多元醇、二异氰酸酯或多异氰酸酯和扩链剂），可以合成用于抗癌 DDS 技术的 PU。目前，关于用于肿瘤治疗的聚氨酯 DDS（PU-DDS）的综合报告很少。本研究综述了用于抗癌 PU-DDS 的新型 PU 的设计。我们研究了获得 PU 作为肿瘤学生物材料的有效方法的成功应用和进一步发展的前景。
