Pfeilschifter J, Minne H W, Enzmann E, Krempien B, Ziegler R
Bone. 1985;6(6):461-5. doi: 10.1016/8756-3282(85)90225-x.
Recent studies have established that generalized loss of trabecular bone occurs in the growing rat following day-to-day inflammatory irritation for a period of 3 wk. We can now demonstrate that there are similar effects on bone in milder but more prolonged chronic inflammation (14 wk). Thus, there were significant decreases in trabecular bone mass as well as in cortical bone after weekly subcutaneous injections or implantations of nonspecific irritants. Osteopenia, induced by a single but extensive inflammatory lesion, remained apparent even 14 wk after induction. This indicates that inflammation-mediated osteopenia is at least incompletely reversible. A less pronounced but similar reduction of cortical and trabecular bone was observed in rats following sham operation. This might be of importance in all animal studies on bone metabolism that include surgical procedures.
最近的研究表明，在生长中的大鼠中，连续3周每天进行炎性刺激会导致小梁骨普遍流失。我们现在可以证明，在较轻但持续时间更长的慢性炎症（14周）中，对骨骼也有类似影响。因此，每周皮下注射或植入非特异性刺激物后，小梁骨量和皮质骨均显著减少。由单个但广泛的炎性病变引起的骨质减少，即使在诱导后14周仍很明显。这表明炎症介导的骨质减少至少是不完全可逆的。在假手术大鼠中观察到皮质骨和小梁骨有不太明显但类似的减少。这在所有包括外科手术的骨代谢动物研究中可能很重要。
