Bakhshpour-Yücel Monireh, Aljayyousi Nawal, Osman Bilgen, Lortlar Ünlü Nese, Denizli Adil, Ünlü M Selim
Department of Chemistry, Faculty of Science and Art, Bursa Uludag University, Bursa 16059, Turkey.
Faculty of Medicine, Histology and Embryology, Atlas University, İstanbul 34403, Turkey.
Sensors (Basel). 2025 May 22;25(11):3256. doi: 10.3390/s25113256.
This review explores the application of nanomaterial-based sensing systems for precisely detecting neuropharmaceutical compounds and neurotransmitters, delving into the connections between nanotechnology and neuropharmacology. Nanotechnology appears as a promising solution for many significant challenges posed by the complexities of the brain's biochemical nature. Using nanoscale materials, scientists have created novel sensors with high selectivity, sensitivity, and adaptability. Developing neuropharmaceutical compounds and monitoring their side effects on our neurological system raised the need for these nanomaterial-based sensors. In this review, we demonstrate the effectiveness of these technologies in real-time neuroactive compound detection and monitoring by illuminating the underlying principles through an examination of significant studies and recent developments. This review also highlights collaborative efforts at the intersection of nanotechnology and neuropharmacology and their direct and indirect effects on the understanding and controlling several neurological disorders. This review covers both sensors under research and those already applied in vivo or clinical monitoring of drug side effects.
本综述探讨了基于纳米材料的传感系统在精确检测神经药物化合物和神经递质方面的应用，深入研究了纳米技术与神经药理学之间的联系。纳米技术似乎是应对大脑生化性质复杂性带来的诸多重大挑战的一个有前景的解决方案。科学家们利用纳米级材料创造了具有高选择性、灵敏度和适应性的新型传感器。开发神经药物化合物并监测其对我们神经系统的副作用，引发了对这些基于纳米材料的传感器的需求。在本综述中，我们通过审视重要研究和最新进展来阐明其基本原理，从而展示这些技术在实时检测和监测神经活性化合物方面的有效性。本综述还强调了纳米技术与神经药理学交叉领域的合作努力，以及它们对理解和控制几种神经系统疾病的直接和间接影响。本综述涵盖了正在研究的传感器以及已经应用于体内或药物副作用临床监测的传感器。
