在碳酸镧原料药中使用4-甲基磺酰苯胺修饰的金纳米颗粒比色法检测铂（IV）
Colorimetric Detection of Platinum (IV) Using 4-MethylSulfonylaniline-Modified Gold Nanoparticles in Lanthanum Carbonate API.
作者信息
Li Zhongqiu, Li Longwei, Yang Xiaotian, Duan Mengtao, Li Zhiwei, Sun Shiguo
机构信息
College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Road, Shijiazhuang 050018, China.
State Key Laboratory Breeding Base-Hebei Key Laboratory of Molecular Chemistry for Drug, 26 Yuxiang Road, Shijiazhuang 050018, China.
出版信息
Sensors (Basel). 2025 May 23;25(11):3274. doi: 10.3390/s25113274.
The control of elemental impurities is a critical step in the preparation of lanthanum carbonate, with platinum being one such impurity. Residual platinum is typically non-therapeutic and must be strictly controlled to ensure both safety and product quality. This paper describes a colorimetric method for determining platinum (IV) in solutions based on the anti-aggregation of gold nanoparticles modified with 4-methylsulfonylaniline (4-MESA). The presence of Britton-Robinson buffer induces the aggregation of the 4-MESA-AuNPs nanoparticle probe. However, when platinum (IV) is introduced, it disrupts the aggregation of the 4-MESA-AuNPs, causing a color change in the solution. The absorbance at 524 nm showed a strong linear correlation in the concentration range of 1.00 × 10 μM to 5.00 × 10 μM. Under optimal conditions, LOD and LOQ values of 10.00 × 10 μM and 3.03 × 10 μM, respectively, were observed. This method has been successfully applied to the determination of platinum (IV) in lanthanum carbonate API.
元素杂质的控制是碳酸镧制备过程中的关键步骤，铂就是其中一种杂质。残留的铂通常无治疗作用，必须严格控制以确保安全性和产品质量。本文描述了一种基于4-甲基磺酰苯胺（4-MESA）修饰的金纳米颗粒的抗聚集作用来测定溶液中铂（IV）的比色法。 Britton-Robinson缓冲液的存在会诱导4-MESA-AuNPs纳米颗粒探针发生聚集。然而，当引入铂（IV）时，它会破坏4-MESA-AuNPs的聚集，导致溶液颜色发生变化。在1.00×10 μM至5.00×10 μM的浓度范围内，524 nm处的吸光度呈现出很强的线性相关性。在最佳条件下，检测限（LOD）和定量限（LOQ）分别为10.00×10 μM和3.03×10 μM。该方法已成功应用于碳酸镧原料药中铂（IV）的测定。
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