McMillin J M, Seal U S, Doe R P
Invest Urol. 1977 Sep;15(2):151-4.
We studied the effects of estramustine phosphate on pituitary, gonadal, and adrenal function in the green monkey. A 2-week course of estramustine phosphate (75 mg per day) reversibly suppressed the luteinizing hormone and testosterone response to luteinizing hormone-releasing hormone but did not affect pituitary-adrenal function assessed by the 11-deoxycorticosterone response to metyrapone. Treatment with oral estramustine phosphate also resulted in a significant increase in corticosteroid-binding globulin but did not affect a series of liver enzymes nor hematology. The results are consistent with a pure estrogen effect produced by hydrolysis of the carbamate-ester bona at a site distant from estrogen target tissues and could explain most of the reported in vivo effects of this compound.
我们研究了磷酸雌莫司汀对绿猴垂体、性腺和肾上腺功能的影响。为期2周的磷酸雌莫司汀疗程（每天75毫克）可可逆性抑制黄体生成素以及睾酮对促黄体生成素释放激素的反应，但不影响通过11-脱氧皮质酮对甲吡酮的反应所评估的垂体-肾上腺功能。口服磷酸雌莫司汀治疗还导致皮质类固醇结合球蛋白显著增加，但不影响一系列肝酶和血液学指标。这些结果与在远离雌激素靶组织的位点处氨基甲酸酯酯键水解产生的纯雌激素效应一致，并且可以解释该化合物大多数已报道的体内效应。
