Jost Wolfgang H, Koschel Jiri
Parkinson-Klinik Ortenau, Kreuzbergstraße 12-16, Wolfach 77709, Germany.
Parkinson-Klinik Ortenau, Wolfach, Germany.
Ther Adv Neurol Disord. 2025 Sep 16;18:17562864251375181. doi: 10.1177/17562864251375181. eCollection 2025.
Cardiovascular symptoms are common in Parkinson's disease (PD), either as non-motor symptoms (NMS) of PD or as coexisting cardiovascular diseases (CVD), since both PD and CVD primarily affect the elderly population. Autonomic dysfunction in PD often involves blood pressure issues, including orthostatic hypotension, postprandial hypotension, and supine hypertension (SH). The combination of these NMS is particularly challenging to diagnose and treat. Other atherosclerotic vascular diseases, such as stroke or myocardial infarction, appear to be more common in PD patients. Prophylactic measures, such as statins or managing hypertension/SH, are essential for PD patients with an elevated risk of CVD, although PD patients usually undergo polypharmacy due to the short half-life of levodopa and the requirement of multiple drugs for CVD. This review presents studies in the literature on the current state-of-the-art therapy for CVD in PD.
心血管症状在帕金森病（PD）中很常见，既可以作为PD的非运动症状（NMS），也可以作为并存的心血管疾病（CVD），因为PD和CVD主要影响老年人群。PD中的自主神经功能障碍常涉及血压问题，包括体位性低血压、餐后低血压和卧位高血压（SH）。这些NMS的组合在诊断和治疗上特别具有挑战性。其他动脉粥样硬化性血管疾病，如中风或心肌梗死，在PD患者中似乎更为常见。对于有CVD风险升高的PD患者，预防性措施，如使用他汀类药物或控制高血压/SH至关重要，尽管由于左旋多巴半衰期短以及CVD需要多种药物治疗，PD患者通常会接受多种药物治疗。本综述介绍了文献中关于PD中CVD当前最先进治疗方法的研究。
