• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

重症监护病房中用于急性创伤性脑损伤的扩散光学断层扫描系统：对健康志愿者的前瞻性研究

Diffuse optical tomography system for acute traumatic brain injury in the intensive care unit: a prospective study on healthy volunteers.

作者信息

Forcione Mario, Chiarelli Antonio Maria, Perpetuini David, Perkins Guy A, Stevens Andrew R, Davies David J, Belli Antonio

机构信息

University of Birmingham, Institute of Inflammation & Ageing, College of Medical and Dental Sciences, Neuroscience & Ophthalmology Research Group, Birmingham, United Kingdom.

University of Milan-Bicocca, School Medicine and Surgery, Milan, Italy.

出版信息

J Biomed Opt. 2025 Feb;30(Suppl 2):S23912. doi: 10.1117/1.JBO.30.S2.S23912. Epub 2025 Sep 17.

DOI:10.1117/1.JBO.30.S2.S23912
PMID:40969780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12443069/
Abstract

SIGNIFICANCE

Invasive neuromonitoring hinders the application of diffuse optical tomography (DOT) to critically ill adults in the intensive care unit (ICU).

AIM

We aim to develop and test a method for DOT recordings suitable for traumatic brain injury (TBI) patients in the ICU. This method is based on measurements and coregistration using a 3D optical scan and the acquisition of optical data using a custom-made helmet, which would enable a multimodal (invasive and noninvasive) neuromonitoring.

APPROACH

Coregistration accuracy between the method based on a 3D optical scan and one based on an electromagnetic digitization, the latter considered to be the gold standard, was assessed. The capacity to isolate and monitor, using functional near-infrared spectroscopy, the optical signal in the intracranial (ICT), and extracranial tissues (ECT), was tested on 23 healthy volunteers. Participants were scanned with a frequency-domain NIRS device (690 and 830 nm) during 5 Valsalva maneuvers (VM) in a simulated ICU environment.

RESULTS

The results showed an average error of coregistration of 5.5 mm and a sufficient capacity to isolate oxyhemoglobin ( ) ( ) and total hemoglobin (HbT) ( ) in the ICT from the ECT and to follow the changes of hemoglobin in the ICT during the VM ( , ; HbT, ).

CONCLUSION

The developed approach appears to be suitable for use on TBI patients in the ICU in a multimodal monitoring.

摘要

意义

侵入性神经监测阻碍了扩散光学断层扫描（DOT）在重症监护病房（ICU）危重症成人患者中的应用。

目的

我们旨在开发并测试一种适用于ICU中创伤性脑损伤（TBI）患者的DOT记录方法。该方法基于使用三维光学扫描进行测量和配准，并使用定制头盔采集光学数据，这将实现多模态（侵入性和非侵入性）神经监测。

方法

评估了基于三维光学扫描的方法与基于电磁数字化的方法（后者被视为金标准）之间的配准精度。在23名健康志愿者身上测试了使用功能近红外光谱法分离和监测颅内（ICT）和颅外组织（ECT）中光信号的能力。在模拟ICU环境中，参与者在5次瓦尔萨尔瓦动作（VM）期间用频域近红外光谱设备（690和830nm）进行扫描。

结果

结果显示配准平均误差为5.5mm，并且有足够的能力从ECT中分离出ICT中的氧合血红蛋白（ ）（ ）和总血红蛋白（HbT）（ ），并在VM期间跟踪ICT中血红蛋白的变化（ ， ；HbT， ）。

结论

所开发的方法似乎适用于ICU中TBI患者的多模态监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b6d/12443069/02f2f688079d/JBO-030-S23912-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b6d/12443069/0b6f4542fd09/JBO-030-S23912-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b6d/12443069/7bacffd7ef37/JBO-030-S23912-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b6d/12443069/a74c8fa7fd1a/JBO-030-S23912-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b6d/12443069/956c6039b3b1/JBO-030-S23912-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b6d/12443069/3f586d1ef23d/JBO-030-S23912-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b6d/12443069/02f2f688079d/JBO-030-S23912-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b6d/12443069/0b6f4542fd09/JBO-030-S23912-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b6d/12443069/7bacffd7ef37/JBO-030-S23912-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b6d/12443069/a74c8fa7fd1a/JBO-030-S23912-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b6d/12443069/956c6039b3b1/JBO-030-S23912-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b6d/12443069/3f586d1ef23d/JBO-030-S23912-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b6d/12443069/02f2f688079d/JBO-030-S23912-g006.jpg

相似文献

1
Diffuse optical tomography system for acute traumatic brain injury in the intensive care unit: a prospective study on healthy volunteers.重症监护病房中用于急性创伤性脑损伤的扩散光学断层扫描系统：对健康志愿者的前瞻性研究
J Biomed Opt. 2025 Feb;30(Suppl 2):S23912. doi: 10.1117/1.JBO.30.S2.S23912. Epub 2025 Sep 17.
2
The effectiveness of interventions to meet family needs of critically ill patients in an adult intensive care unit: a systematic review update.成人重症监护病房中满足重症患者家庭需求的干预措施的有效性：系统评价更新
JBI Database System Rev Implement Rep. 2016 Mar;14(3):181-234. doi: 10.11124/JBISRIR-2016-2477.
3
Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) for the diagnosis of delirium in adults in critical care settings.**用于** ICU 成人患者的意识模糊评估方法（CAM-ICU）**用于** 诊断重症监护环境下成人的意识障碍。
Cochrane Database Syst Rev. 2023 Nov 21;11(11):CD013126. doi: 10.1002/14651858.CD013126.pub2.
4
Melatonin for the promotion of sleep in adults in the intensive care unit.褪黑素用于促进重症监护病房成年患者的睡眠。
Cochrane Database Syst Rev. 2018 May 10;5(5):CD012455. doi: 10.1002/14651858.CD012455.pub2.
5
Cerebral near-infrared spectroscopy (NIRS) for perioperative monitoring of brain oxygenation in children and adults.用于儿童和成人围手术期脑氧合监测的脑近红外光谱技术（NIRS）。
Cochrane Database Syst Rev. 2018 Jan 17;1(1):CD010947. doi: 10.1002/14651858.CD010947.pub2.
6
Routine intracranial pressure monitoring in acute coma.急性昏迷患者的常规颅内压监测
Cochrane Database Syst Rev. 2015 Nov 2;2015(11):CD002043. doi: 10.1002/14651858.CD002043.pub3.
7
Extracorporeal carbon dioxide removal for the treatment of acute hypoxaemic respiratory failure: the REST RCT.体外二氧化碳清除治疗急性低氧性呼吸衰竭：REST随机对照试验
Health Technol Assess. 2025 Jul;29(33):1-16. doi: 10.3310/GJDM0320.
8
Exercise rehabilitation following intensive care unit discharge for recovery from critical illness.重症监护病房出院后进行运动康复以促进危重症恢复。
Cochrane Database Syst Rev. 2015 Jun 22;2015(6):CD008632. doi: 10.1002/14651858.CD008632.pub2.
9
Early intervention (mobilization or active exercise) for critically ill adults in the intensive care unit.对重症监护病房中的成年重症患者进行早期干预（活动或主动锻炼）。
Cochrane Database Syst Rev. 2018 Mar 27;3(3):CD010754. doi: 10.1002/14651858.CD010754.pub2.
10
Technological aids for the rehabilitation of memory and executive functioning in children and adolescents with acquired brain injury.脑损伤儿童和青少年记忆与执行功能康复的技术辅助手段。
Cochrane Database Syst Rev. 2016 Jul 1;7(7):CD011020. doi: 10.1002/14651858.CD011020.pub2.