Ukolova Elizabet, Hanková Marie, Lustigová Michala
Faculty of Science, Department of Demography and Geodemography Charles University Prague Czechia.
Interdisciplinary Centre on Population Dynamics (CPop) University of Southern Denmark Odense Denmark.
Health Sci Rep. 2025 Sep 17;8(9):e71164. doi: 10.1002/hsr2.71164. eCollection 2025 Sep.
Patients with Rheumatoid diseases (AR) are at higher risk for depressive symptoms. This study aims to identify key depressive symptoms that lead to the accumulation of additional symptoms over time, using Survey of Health, Ageing and Retirement in Europe (SHARE) data from year during the follow up period 2015-2019/2020 (sample size 32,082 individuals).
We applied network analysis, where nodes represent depressive symptoms by EURO-D scale and edges are weighted by odds ratios. Changes in symptom relationships were analysed by transitions between health states: "healthy," "AR only," and "AR with additional comorbidity."
To prevent further depressive symptom accumulation in AR patients, addressing irritability and lack of interest is crucial. In males, loss of appetite should also be targeted, while in females, depressive feelings need specific attention. Males with AR and additional comorbidities show a significant increase in symptom network density, while females have stronger associations with interest, appetite, guilt, and depression.
AR is associated with significant changes in the structure of depressive symptom networks, varying with health progression. Attention to irritability, lack of interest, appetite, and depressive feelings is crucial for preventing further mental health declines in newly diagnosed AR patients.
类风湿疾病（AR）患者出现抑郁症状的风险更高。本研究旨在利用2015 - 2019/2020年随访期间欧洲健康、老龄化与退休调查（SHARE）的数据（样本量为32082人），确定随着时间推移会导致更多症状累积的关键抑郁症状。
我们应用网络分析，其中节点由EURO - D量表表示抑郁症状，边由优势比加权。通过健康状态之间的转变分析症状关系的变化：“健康”、“仅患AR”和“患AR且有其他合并症”。
为防止AR患者进一步出现抑郁症状累积，解决易怒和缺乏兴趣的问题至关重要。对于男性，还应关注食欲不振，而对于女性，抑郁情绪需要特别关注。患有AR且有其他合并症的男性症状网络密度显著增加，而女性与兴趣、食欲、内疚和抑郁的关联更强。
AR与抑郁症状网络结构的显著变化相关，随健康进展而变化。关注易怒、缺乏兴趣、食欲和抑郁情绪对于防止新诊断的AR患者心理健康进一步下降至关重要。
