• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

血小板减少对兔实验性动脉粥样硬化病变形成的影响。平滑肌细胞增殖和再内皮化。

The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits. Smooth muscle cell proliferation and re-endothelialization.

作者信息

Friedman R J, Stemerman M B, Wenz B, Moore S, Gauldie J, Gent M, Tiell M L, Spaet H

出版信息

J Clin Invest. 1977 Nov;60(5):1191-201. doi: 10.1172/JCI108872.

DOI:10.1172/JCI108872
PMID:409735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC372473/
Abstract

This study was designed to investigate the mechanisms involved in fibromusculoelastic lesion formation produced by selective de-endothelialization by the intra-arterial balloon catheter technique in thrombocytopenic rabbits. Thrombocytopenia was induced and maintained for up to 30 days by daily injections fo highly specific sheep anti-rabbit platelet sera (APS). Evidence for re-endothelialization was obtained by i.v. Evans blue dye 30 min before sacrifice. Rabbits received daily injections of APS, which reduced the mean platelet count to 5,600/cm3; control animals received identically treated normal sheep sera on the same schedule, and had mean daily platelet counts of 363,000/cm3. Evaluation of intimal thickness was assessed by counting cell layers in semithin sections. Intimal thickening in aortae from rabbits treated with APS was strikingly suppressed, in contrast to those from normal sheep sera-treated animals which showed a mean intimal thickness of 18 cell layers within 28 days often after de-endothelialization. Re-endothelialization was not affected by APS treatment. These results indicate that the proliferation of smooth muscle cells is dramatically inhibited by reduction of platelets.

摘要

本研究旨在探讨在血小板减少的兔中，通过动脉内球囊导管技术进行选择性去内皮化所产生的纤维肌弹性病变形成的相关机制。通过每日注射高特异性羊抗兔血小板血清（APS）诱导并维持血小板减少长达30天。在处死前30分钟经静脉注射伊文思蓝染料以获得再内皮化的证据。兔每日注射APS，其平均血小板计数降至5600/mm³；对照动物按相同方案注射经同样处理的正常羊血清，平均每日血小板计数为363000/mm³。通过计数半薄切片中的细胞层数来评估内膜厚度。与正常羊血清处理的动物相比，接受APS处理的兔主动脉内膜增厚受到显著抑制，正常羊血清处理的动物在去内皮化后28天内平均内膜厚度为18个细胞层。再内皮化不受APS处理的影响。这些结果表明，血小板减少可显著抑制平滑肌细胞的增殖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ce/372473/afbe0965859f/jcinvest00659-0237-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ce/372473/acae1a33c097/jcinvest00659-0234-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ce/372473/fb74d2e66cb4/jcinvest00659-0235-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ce/372473/d93f482a445b/jcinvest00659-0236-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ce/372473/883f470733be/jcinvest00659-0236-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ce/372473/afbe0965859f/jcinvest00659-0237-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ce/372473/acae1a33c097/jcinvest00659-0234-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ce/372473/fb74d2e66cb4/jcinvest00659-0235-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ce/372473/d93f482a445b/jcinvest00659-0236-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ce/372473/883f470733be/jcinvest00659-0236-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56ce/372473/afbe0965859f/jcinvest00659-0237-a.jpg

相似文献

1
The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits. Smooth muscle cell proliferation and re-endothelialization.血小板减少对兔实验性动脉粥样硬化病变形成的影响。平滑肌细胞增殖和再内皮化。
J Clin Invest. 1977 Nov;60(5):1191-201. doi: 10.1172/JCI108872.
2
Inhibition of injury induced thromboatherosclerotic lesions by anti-platelet serum in rabbits.抗血小板血清对兔损伤诱导的血栓动脉粥样硬化病变的抑制作用。
Thromb Haemost. 1976 Feb 29;35(1):70-81.
3
Continued platelet interaction with de-endothelialized aortae associated with slower re-endothelialization and more extensive intimal hyperplasia in spontaneously diabetic BB Wistar rats.在自发性糖尿病BB Wistar大鼠中，血小板与去内皮化主动脉的持续相互作用与再内皮化减慢及更广泛的内膜增生相关。
Int J Exp Pathol. 1993 Dec;74(6):603-13.
4
Suppression of neointimal thickening by a newly developed HMG-CoA reductase inhibitor, BAYw6228, and its inhibitory effect on vascular smooth muscle cell growth.一种新开发的HMG-CoA还原酶抑制剂BAYw6228对新生内膜增厚的抑制作用及其对血管平滑肌细胞生长的抑制作用。
Br J Pharmacol. 1997 Mar;120(6):1172-8. doi: 10.1038/sj.bjp.0701018.
5
Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.同型胱氨酸诱导的动脉硬化。内皮细胞损伤和血小板反应在其发生过程中的作用。
J Clin Invest. 1976 Sep;58(3):731-41. doi: 10.1172/JCI108520.
6
Failure of certain antiplatelet drugs to affect myointimal thickening following arterial endothelial injury in the rat.某些抗血小板药物对大鼠动脉内皮损伤后肌内膜增厚无影响。
Lab Invest. 1977 Apr;36(4):452-64.
7
Spontaneous diabetes in BB Wistar rats causes small increases in the early proliferative response of smooth muscle cells in re-injured aortae.BB 系 Wistar 大鼠的自发性糖尿病会导致再次损伤的主动脉中平滑肌细胞的早期增殖反应略有增加。
Exp Mol Pathol. 1995 Dec;63(3):161-74. doi: 10.1006/exmp.1995.1040.
8
Influence of platelet count on haemostatic plug formation and plug stability. An experimental study in rabbits with graded thrombocytopenia.血小板计数对止血栓形成及血栓稳定性的影响。对血小板减少程度分级的家兔进行的一项实验研究。
Thromb Diath Haemorrh. 1973 Dec 31;30(3):586-96.
9
Role of endothelium and hypercholesterolemia in intimal thickening and lipid accumulation.内皮细胞和高胆固醇血症在内膜增厚和脂质蓄积中的作用。
Am J Pathol. 1979 Apr;95(1):131-58.
10
The effect of massive liver resection on platelet kinetics in the rat.大鼠大规模肝切除对血小板动力学的影响。
J Lab Clin Med. 1975 Nov;86(5):817-33.

引用本文的文献

1
Impacts of Polymorphism and Clopidogrel Dosing on in-Stent Restenosis: A Retrospective Cohort Study in Chinese Patients.基因多态性和氯吡格雷剂量对支架内再狭窄的影响：中国患者的回顾性队列研究。
Drug Des Devel Ther. 2020 Feb 19;14:669-676. doi: 10.2147/DDDT.S242167. eCollection 2020.
2
Enhanced biocompatibility of CD47-functionalized vascular stents.CD47功能化血管支架的生物相容性增强
Biomaterials. 2016 May;87:82-92. doi: 10.1016/j.biomaterials.2016.02.008. Epub 2016 Feb 8.
3
Healing arterial ulcers: Endothelial lining regeneration upon vascular denudation injury.

本文引用的文献

1
Morphology and enumeration of human blood platelets.人体血小板的形态学与计数
J Appl Physiol. 1950 Dec;3(6):365-77. doi: 10.1152/jappl.1950.3.6.365.
2
IMMUNOCHEMICAL STUDIES OF THE RH SYSTEM. I. ISOLATION AND CHARACTERIZATION OF ANTIBODIES.RH系统的免疫化学研究。I. 抗体的分离与特性鉴定
J Immunol. 1964 May;92:682-92.
3
[Effects of vascular catheterization in normo- and hypercholesteremic rabbits].[血管插管对正常胆固醇血症和高胆固醇血症兔的影响]
愈合动脉溃疡：血管剥脱损伤后内皮衬里再生。
Vascul Pharmacol. 2015 Sep;72:9-15. doi: 10.1016/j.vph.2015.06.007. Epub 2015 Jun 18.
4
Pharmacological approaches to the prevention of restenosis after coronary angioplasty.
Drugs Aging. 1998 Oct;13(4):291-301. doi: 10.2165/00002512-199813040-00005.
5
Proliferative response of human and minipig smooth muscle cells after coronary angioplasty to growth factors and platelets.冠状动脉血管成形术后人和小型猪平滑肌细胞对生长因子及血小板的增殖反应
Basic Res Cardiol. 1996 Nov-Dec;91(6):407-17. doi: 10.1007/BF00788721.
6
Separation of the arterial wall from blood contact using hydrogel barriers reduces intimal thickening after balloon injury in the rat: the roles of medial and luminal factors in arterial healing.使用水凝胶屏障将动脉壁与血液接触分离可减少大鼠球囊损伤后的内膜增厚：中膜和管腔因素在动脉愈合中的作用。
Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13188-93. doi: 10.1073/pnas.93.23.13188.
7
Localization of Fos and Jun proteins in rat aortic smooth muscle cells after vascular injury.血管损伤后大鼠主动脉平滑肌细胞中Fos和Jun蛋白的定位
Am J Pathol. 1993 Mar;142(3):715-24.
8
Platelet activation releases megakaryocyte-synthesized apolipoprotein J, a highly abundant protein in atheromatous lesions.血小板活化会释放巨核细胞合成的载脂蛋白J，这是一种在动脉粥样硬化病变中含量很高的蛋白质。
Am J Pathol. 1993 Sep;143(3):763-73.
9
Failure of epoprostenol (prostacyclin, PGI2) to inhibit platelet aggregation and to prevent restenosis after coronary angioplasty: results of a randomised placebo controlled trial.依前列醇（前列环素，PGI2）在冠状动脉血管成形术后未能抑制血小板聚集及预防再狭窄：一项随机安慰剂对照试验的结果
Br Heart J. 1994 Jan;71(1):7-15. doi: 10.1136/hrt.71.1.7.
10
Continued platelet interaction with de-endothelialized aortae associated with slower re-endothelialization and more extensive intimal hyperplasia in spontaneously diabetic BB Wistar rats.在自发性糖尿病BB Wistar大鼠中，血小板与去内皮化主动脉的持续相互作用与再内皮化减慢及更广泛的内膜增生相关。
Int J Exp Pathol. 1993 Dec;74(6):603-13.
Pathol Microbiol (Basel). 1966;29(4):393-405.
4
An improved automated determination of serum total cholesterol with a single color reagent.用单一颜色试剂改进血清总胆固醇的自动测定方法。
Clin Chem. 1966 Oct;12(10):681-9.
5
Experimental induction of athero-arteriosclerosis by the synergy of allergic injury to arteries and lipid-rich diet. I. Effect of repeated injections of horse serum in rabbits fed a dietary cholesterol supplement.通过动脉过敏性损伤与富含脂质饮食的协同作用实验诱导动脉粥样硬化。I. 在喂食胆固醇补充剂的兔子中重复注射马血清的效果。
J Exp Med. 1966 Oct 1;124(4):635-52. doi: 10.1084/jem.124.4.635.
6
Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test.同种移植的血清分型。18. 微滴淋巴细胞细胞毒性试验的改进。
Transplantation. 1968 Nov;6(8):913-27. doi: 10.1097/00007890-196811000-00006.
7
Behavior of smooth muscle cells and formation of extracellular structures in the reaction of arterial walls to injury.动脉壁损伤反应中平滑肌细胞的行为及细胞外结构的形成
Am J Pathol. 1971 Mar;62(3):391-414.
8
Improved accuracy in automated fluorometric determination of plasma triglycerides.自动荧光法测定血浆甘油三酯的准确性提高。
Clin Chem. 1970 Mar;16(3):166-70.
9
Arterial repair and atherosclerosis after mechanical injury. 2. Tissue response after induction of a total local necrosis deep longitudinal injury.
Atherosclerosis. 1971 Sep-Oct;14(2):259-76. doi: 10.1016/0021-9150(71)90055-4.
10
Adenosine diphosphate-induced platelet aggregation in suspensions of washed rabbit platelets.洗涤过的兔血小板悬液中，二磷酸腺苷诱导的血小板聚集。
Br J Haematol. 1970 Jul;19(1):7-17. doi: 10.1111/j.1365-2141.1970.tb01596.x.