Al-Maweri Sadeq A, Al-Qadhi Gamilah, Alqutaibi Ahmed Yaseen, Sallam Nadhem M, Assad Mounzer, Abdulghani Mahfoudh A, Mohammed Marwan Mansoor Ali
College of Dental Medicine, QU Health, Qatar University, Doha, Qatar.
Department of Basic Dental Sciences, Faculty of Dentistry, University of Science and Technology, Aden, Yemen.
Clin Exp Dent Res. 2025 Oct;11(5):e70227. doi: 10.1002/cre2.70227.
The management of oral lichen planus (OLP) is challenging, with no definitive cure available. This systematic review and meta-analysis aimed to assess the efficacy of curcumin in managing OLP.
A comprehensive search of PubMed, Scopus, Web of Science, and Google Scholar was conducted for relevant clinical trials published up to March 31, 2025. All clinical trials comparing the efficacy of curcumin to corticosteroids were included. A meta-analysis was conducted on studies with available numerical data to assess the efficacy of curcumin relative to the control group.
Eleven clinical trials, involving 499 OLP patients, were included in this review, with nine studies were incorporated into the meta-analysis. All studies reported curcumin to be efficacious in alleviating the signs and symptoms of OLP. Pooled data showed significantly better efficacy of curcumin in reducing pain at 1 week (SMD, -0.70; 95% CI, -1.33, -0.07; p = 0.03; I = 66%) compared with corticosteroids. However, no significant differences were observed between the two groups at the 2-, 4-, and 12-week follow-ups. Additionally, curcumin and corticosteroids demonstrated comparable efficacy in clinical improvement of lesions across different time points.
The available evidence suggests that curcumin has promising effects in managing OLP. However, due to methodological limitations, including significant heterogeneity among the studies and a high risk of bias in most of them, further well-designed studies with adequate follow-up periods are needed.
口腔扁平苔藓（OLP）的治疗具有挑战性，尚无确切的治愈方法。本系统评价和荟萃分析旨在评估姜黄素治疗OLP的疗效。
对截至2025年3月31日发表的相关临床试验进行了全面检索，检索数据库包括PubMed、Scopus、Web of Science和谷歌学术。纳入所有比较姜黄素与皮质类固醇疗效的临床试验。对有可用数值数据的研究进行荟萃分析，以评估姜黄素相对于对照组的疗效。
本评价纳入了11项临床试验，涉及499例OLP患者，其中9项研究纳入了荟萃分析。所有研究均报告姜黄素在减轻OLP的体征和症状方面有效。汇总数据显示，与皮质类固醇相比，姜黄素在1周时减轻疼痛的疗效显著更好（标准化均数差，-0.70；95%置信区间，-1.33，-0.07；p = 0.03；I² = 66%）。然而，在2周、4周和12周的随访中，两组之间未观察到显著差异。此外，在不同时间点，姜黄素和皮质类固醇在病变临床改善方面显示出相当的疗效。
现有证据表明姜黄素在治疗OLP方面具有良好的效果。然而，由于方法学上的局限性，包括研究之间存在显著异质性且大多数研究存在较高的偏倚风险，因此需要进一步开展设计良好且随访期充足的研究。
