Totou Nádia Lúcia, Rocha Ana Maria Sampaio, de Moura Samara Silva, Pereira César Henrique, Coelho Fabricio Sampaio, Dophine Douglas Daniel, Coelho Daniel Barbosa, de Oliveira Emerson Cruz, Dos Santos Robson Augusto Souza, Becker Lenice Kappes, de Lima Wanderson Geraldo
Biological Sciences Research Center-Postgraduate Program in Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Brazil.
School of Physical Education, Federal University of Ouro Preto, Ouro Preto, Brazil.
J Cell Mol Med. 2025 Sep;29(18):e70851. doi: 10.1111/jcmm.70851.
To evaluate the therapeutic effect of oral treatment with HPβ-CD-angiotensin-(1-7) (Ang-(1-7)) on muscle recovery after laceration injury. Wistar rats were divided into four groups: Control (n = 10); HPβ-CD-Ang-(1-7) (n = 10); muscle injury + HPβ-CD (MI + Placebo) (n = 24); and muscle injury + HPβ-CD-Ang-(1-7) (MI + Ang-(1-7)) (n = 24). After 7-21 days of treatment, physical performance, histological features and the expression of pro- and anti-fibrotic genes were evaluated. The MI + Ang-(1-7) group showed improved control of the inflammatory phase and reduced deposition of collagen types I and III compared to MI + Placebo. CTGF gene expression analysis revealed lower levels of pro-fibrotic markers and higher expression of proteins involved in blocking fibrotic pathways. In treadmill tests, MI + Ang-(1-7) animals also showed superior physical performance at all evaluated time points. Oral treatment with Ang-(1-7) is effective in promoting recovery from muscle injuries, particularly fibrotic lesions, while preserving muscle function and enhancing physical performance.
