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睑内翻作为结膜下上皮样血管内皮瘤的一种临床表现:一例罕见病例报告。

Trichiasis as a clinical manifestation of subconjunctival epithelioid hemangioendothelioma: a rare case report.

作者信息

Hu Mingjue, Wang Jinlin, Zhou Sirui, Chen Yuanyuan, Luo Ting, Guo Juan, Wang Zhanfeng, Sun Yi

机构信息

Department of Ophthalmology, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China.

Department of Pathology, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China.

出版信息

Front Oncol. 2025 Sep 4;15:1638365. doi: 10.3389/fonc.2025.1638365. eCollection 2025.

Abstract

Epithelioid hemangioendothelioma(EHE) is a rare, low-grade malignant tumor of vascular endothelial origin, commonly found in the lungs, liver, bones, and soft tissue. However, orbital involvement is uncommon. This study presents a rare case of EHE located in the orbit and confined to the subconjunctival space which has not been previously documented. An elderly male patient presented with a six-month history of discomfort in his left eye, initially diagnosed with lower eyelid trichiasis and scheduled for surgical intervention. A detailed examination identified a purplish, spherical mass beneath the fornix conjunctiva of the left lower eyelid. Computed tomography (CT) imaging of the orbit revealed a well-defined soft tissue mass beneath the left globe, adjacent to the inferior rectus muscle, with no evidence of invasion into the orbital cavity. Ultrasound showed a hypoechoic mass with abundant internal vascularity. Following complete surgical excision, histopathological analysis confirmed the diagnosis of EHE. Postoperative follow-up revealed no signs of recurrence, with full resolution of the trichiasis. No eye movement disorders or visual abnormalities were observed. Despite its generally low malignancy, EHE carries a risk of recurrence and metastasis. Complete excision is crucial to minimize recurrence risk, and long-term follow-up is essential for optimal management.

摘要

上皮样血管内皮瘤(EHE)是一种罕见的、低级别恶性的血管内皮源性肿瘤,常见于肺、肝、骨和软组织。然而,眼眶受累并不常见。本研究报告了一例罕见的位于眼眶且局限于结膜下间隙的EHE病例,此前尚无相关文献记载。一名老年男性患者因左眼不适6个月前来就诊,最初被诊断为下睑倒睫并计划接受手术干预。详细检查发现左下睑结膜穹窿下方有一个紫色球形肿块。眼眶计算机断层扫描(CT)成像显示左眼球下方有一个边界清晰的软组织肿块,与下直肌相邻,无眶腔侵犯迹象。超声显示为低回声肿块,内部血管丰富。完整手术切除后,组织病理学分析确诊为EHE。术后随访未发现复发迹象,倒睫完全缓解。未观察到眼球运动障碍或视觉异常。尽管EHE总体恶性程度较低,但仍有复发和转移风险。完整切除对于降低复发风险至关重要,长期随访对于优化治疗管理必不可少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebd0/12443531/88144b99bbf8/fonc-15-1638365-g001.jpg

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